AC   MF_01142;
DC   Protein; auto
TR   HAMAP; MF_01142; -; 1; level=0
XX
Names: LrgB
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ID   LRGB
DE   RecName: Full=Antiholin-like protein LrgB;
GN   Name=lrgB;
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case <OC:Staphylococcus>
CC   -!- FUNCTION: Inhibits the expression or activity of extracellular murein
CC       hydrolases by interacting, possibly with LrgA, with the holin-like
CC       proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the
CC       proton motive force of the membrane. May be involved in programmed cell
CC       death (PCD), possibly triggering PCD in response to antibiotics and
CC       environmental stresses.
else
CC   -!- FUNCTION: Inhibits the expression or activity of extracellular murein
CC       hydrolases by interacting, possibly with LrgA, with the holin-like
CC       protein CidA. The LrgAB and CidA proteins may affect the proton motive
CC       force of the membrane. May be involved in programmed cell death (PCD),
CC       possibly triggering PCD in response to antibiotics and environmental
CC       stresses.
end case
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the CidB/LrgB family. LrgB subfamily.
XX
DR   Pfam; PF04172; LrgB; 1; trigger=no
DR   General; Transmembrane; -; 5-7; trigger=yes
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KW   Cell membrane
KW   Cytolysis
KW   Membrane
KW   Transmembrane
KW   Transmembrane helix
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GO   GO:0019835; P:cytolysis
GO   GO:0012501; P:programmed cell death
GO   GO:0005886; C:plasma membrane
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FT   None
XX
Size: 230-233;
Related: None;
Template: P60643;
Scope:
 Bacteria; Bacillota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.20 2023/01/13
//