AC   MF_01145;
DC   Protein; auto
TR   HAMAP; MF_01145; -; 1; level=0
XX
Names: Foldase_PrsA
XX
ID   PRSA
DE   RecName: Full=Foldase protein PrsA;
DE            EC=5.2.1.8;
DE   Flags: Precursor;
GN   Name=prsA;
XX
CC   -!- FUNCTION: Plays a major role in protein secretion by helping the post-
CC       translocational extracellular folding of several secreted proteins.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[protein]-peptidylproline (omega=180) = [protein]-
CC         peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA-
CC         COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833,
CC         ChEBI:CHEBI:83834; EC=5.2.1.8;
case <Feature:PS51257>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor.
end case
CC   -!- SIMILARITY: Belongs to the PrsA family.
XX
DR   Pfam; PF00639; Rotamase; 1; trigger=no
DR   PROSITE; PS01096; PPIC_PPIASE_1; 1; trigger=no
DR   PROSITE; PS50198; PPIC_PPIASE_2; 1; trigger=yes
DR   PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1; trigger=yes
XX
KW   Isomerase
KW   Rotamase
KW   Cell membrane
KW   Membrane
case <Feature:PS51257>
KW   Lipoprotein
KW   Palmitate
end case
KW   Signal
XX
GO   GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity
GO   GO:0006457; P:protein folding
case <Feature:PS51257>
GO   GO:0005886; C:plasma membrane
end case
XX
FT   None
XX
Size: 248-353;
Related: None;
Template: P24327;
Scope:
 Bacteria; Bacillota
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACAN, BACCR, LACJO, LACLC, LACPL, LISIN, LISMO, STRP3, STRP8,
 STRP1
Plasmid: in LACLC
Comments: These proteins are typical of Gram-positive bacteria. They share low
 similarity and may be present in several copies per genome. Some do
 not possess the PPIase domain but are still active as foldases.
XX
# Revision 1.21 2023/01/13
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