AC MF_01146; DC Protein; auto TR HAMAP; MF_01146; -; 1; level=0 XX Names: Aquaporin_Z XX ID AQPZ DE RecName: Full=Aquaporin Z; GN Name=aqpZ; XX CC -!- FUNCTION: Channel that permits osmotically driven movement of water in CC both directions. It is involved in the osmoregulation and in the CC maintenance of cell turgor during volume expansion in rapidly growing CC cells. It mediates rapid entry or exit of water in response to abrupt CC changes in osmolarity. CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O(in) = H2O(out); Xref=Rhea:RHEA:29667, ChEBI:CHEBI:15377; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29668; CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29669; CC -!- SUBUNIT: Homotetramer. case not defined or CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. else case CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. end case case and CC -!- DOMAIN: Aquaporins contain two tandem repeats each containing three CC membrane-spanning domains and a pore-forming loop with the signature CC motif Asn-Pro-Ala (NPA). end case CC -!- SIMILARITY: Belongs to the MIP/aquaporin (TC 1.A.8) family. XX DR Pfam; PF00230; MIP; 1; trigger=no DR PRINTS; PR00783; MINTRINSICP; 1; trigger=no DR NCBIfam; TIGR00861; MIP; 1; trigger=no DR PROSITE; PS00221; MIP; 1; trigger=no DR General; Transmembrane; -; 6; trigger=yes XX KW Transport KW Transmembrane KW Cell membrane KW Membrane case defined and KW Cell inner membrane end case case and KW Repeat end case KW Transmembrane helix XX GO GO:0015250; F:water channel activity GO GO:0005886; C:plasma membrane XX FT From: AQPZ_ECOLI (P60844) FT MOTIF 63..65 FT /note="NPA 1" FT Condition: N-P-A FT MOTIF 186..188 FT /note="NPA 2" FT Condition: N-P-A FT SITE 20 FT /note="Involved in tetramerization or stability of the FT tetramer" FT Condition: C FT SITE 43 FT /note="Selectivity filter" FT Optional; Condition: F FT SITE 174 FT /note="Selectivity filter" FT Optional; Condition: H FT SITE 183 FT /note="Selectivity filter" FT Optional; Condition: T FT SITE 189 FT /note="Selectivity filter" FT Optional; Condition: R XX Size: 170-248; Related: None; Template: P60844; Scope: Bacteria Fusion: Nter: None Cter: None Duplicate: in AGRFC, RHIME Plasmid: in AGRFC, RHIME Comments: None XX # Revision 1.28 2023/06/01 //