AC MF_01151; DC Protein; auto TR HAMAP; MF_01151; -; 1; level=0 XX Names: GrpE XX ID GRPE DE RecName: Full=Protein GrpE; DE AltName: Full=HSP-70 cofactor; GN Name=grpE; XX CC -!- FUNCTION: Participates actively in the response to hyperosmotic and CC heat shock by preventing the aggregation of stress-denatured proteins, CC in association with DnaK and GrpE. It is the nucleotide exchange factor CC for DnaK and may function as a thermosensor. Unfolded proteins bind CC initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK CC hydrolyzes its bound ATP, resulting in the formation of a stable CC complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the CC release of the substrate protein, thus completing the reaction cycle. CC Several rounds of ATP-dependent interactions between DnaJ, DnaK and CC GrpE are required for fully efficient folding. CC -!- SUBUNIT: Homodimer. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the GrpE family. XX DR Pfam; PF01025; GrpE; 1; trigger=no DR PRINTS; PR00773; GRPEPROTEIN; 1; trigger=no DR PROSITE; PS01071; GRPE; 1; trigger=no XX KW Cytoplasm KW Chaperone KW Stress response XX GO GO:0005737; C:cytoplasm XX FT None XX Size: 157-298; Related: None; Template: P09372; Scope: Bacteria Archaea; Euryarchaeota Fusion: Nter: None Cter: None Duplicate: in BUCAI, BUCAP, BUCBP, STRAW Plasmid: None Comments: None XX # Revision 1.16 2019/11/19 //