AC   MF_01158;
DC   Protein; auto
TR   HAMAP; MF_01158; -; 1; level=0
XX
Names: Hda
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ID   HDA
DE   RecName: Full=DnaA regulatory inactivator Hda;
GN   Name=hda;
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CC   -!- FUNCTION: Mediates the interaction of DNA replication inititator
CC       protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN).
CC       Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive
CC       for reinititation, a process called regulatory inhibition of DnaA or
CC       RIDA.
CC   -!- SUBUNIT: The active form seems to be an ADP-bound monomer. Forms the
CC       RIDA complex (regulatory inactivation of DnaA) of ATP-DnaA, ADP-Hda and
CC       the DNA-loaded beta sliding clamp (dnaN).
CC   -!- SIMILARITY: Belongs to the DnaA family. HdA subfamily.
XX
DR   PRINTS; PR00051; DNAA; 1; trigger=no
DR   NCBIfam; TIGR03420; DnaA_homol_Hda; 1; trigger=no
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KW   DNA replication
KW   DNA replication inhibitor
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GO   GO:0006260; P:DNA replication
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FT   None
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Size: 225-248;
Related: None;
Template: P69931;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: In E.coli this has been shown to be initiated from a CUG start
 codon (PubMed:18977760), the first CUG start codon found in E.coli, which
 as it is inefficiently used probably keeps the protein levels low. We have
 propagated this same start site to other Escherichia and Shigella species
 but no further.
XX
# Revision 1.17 2023/06/01
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