AC   MF_01159;
DC   Protein; auto
TR   HAMAP; MF_01159; -; 1; level=0
XX
Names: YabA
XX
ID   YABA
DE   RecName: Full=Replication initiation control protein YabA;
GN   Name=yabA;
XX
CC   -!- FUNCTION: Involved in control of chromosome replication initiation.
CC       Inhibits the cooperative binding of DnaA to the oriC region, thus
CC       negatively regulating initiation of chromosome replication. Inhibits
CC       the ability of DnaA-ATP to form a helix on DNA; does not disassemble
CC       preformed DnaA-DNA helices. Decreases the residence time of DnaA on the
CC       chromosome at its binding sites (oriC, replication forks and promoter-
CC       binding sites). Tethers DnaA to the replication machinery via the DNA
CC       polymerase beta sliding clamp subunit (dnaN). Associates with oriC and
CC       other DnaA targets on the chromosome in a DnaA-dependent manner.
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- SUBUNIT: Homotetramer. Interacts with both DnaA and DnaN, acting as a
CC       bridge between these two proteins.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid. Note=Localizes in tight
CC       foci, which correspond to the replisome at mid-cell throughout the cell
CC       cycle.
CC   -!- SIMILARITY: Belongs to the YabA family.
XX
DR   Pfam; PF06156; DUF972; 1; trigger=no
DR   PIRSF; PIRSF021439; DUF972; 1; trigger=no
XX
KW   Cytoplasm
KW   DNA replication
KW   DNA replication inhibitor
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0008156; P:negative regulation of DNA replication
GO   GO:0043590; C:bacterial nucleoid
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: YABA_BACSU (P37542)
FT   BINDING         95
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: H
FT   BINDING         97
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         109
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         112
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
XX
Size: 105-129;
Related: None;
Template: P37542;
Scope:
 Bacteria; Bacillota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Version: 13
# Last updated date: 2024-11-21
# Created date: 2005-02-28
//