AC   MF_01163;
DC   Protein; auto
TR   HAMAP; MF_01163; -; 1; level=0
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Names: IMP_biosynth_PurP
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ID   PURP
DE   RecName: Full=5-formaminoimidazole-4-carboxamide-1-(beta)-D-ribofuranosyl 5'-monophosphate synthetase;
DE            EC=6.3.4.23;
DE   AltName: Full=5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate--formate ligase;
GN   Name=purP;
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CC   -!- FUNCTION: Catalyzes the ATP- and formate-dependent formylation of 5-
CC       aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate
CC       (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl
CC       5'-monophosphate (FAICAR) in the absence of folates.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide +
CC         ATP + formate = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-
CC         carboxamide + ADP + phosphate; Xref=Rhea:RHEA:24836,
CC         ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58467, ChEBI:CHEBI:58475, ChEBI:CHEBI:456216;
CC         EC=6.3.4.23;
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-
CC       formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-
CC       1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (formate route): step
CC       1/1.
CC   -!- SIMILARITY: Belongs to the phosphohexose mutase family.
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DR   Pfam; PF06849; DUF1246; 1; trigger=no
DR   Pfam; PF06973; DUF1297; 1; trigger=no
DR   PROSITE; PS50975; ATP_GRASP; 1; trigger=yes
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KW   ATP-binding
KW   Ligase
KW   Nucleotide-binding
KW   Purine biosynthesis
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GO   GO:0016879; F:ligase activity, forming carbon-nitrogen bonds
GO   GO:0006189; P:'de novo' IMP biosynthetic process
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FT   From: PURP_PYRFU (Q8U0R7)
FT   BINDING         204
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: E
FT   BINDING         11
FT                   /ligand="5-amino-1-(5-phospho-beta-D-
FT                   ribosyl)imidazole-4-carboxamide"
FT                   /ligand_id="ChEBI:CHEBI:58475"
FT   Condition: H
FT   BINDING         71
FT                   /ligand="5-amino-1-(5-phospho-beta-D-
FT                   ribosyl)imidazole-4-carboxamide"
FT                   /ligand_id="ChEBI:CHEBI:58475"
FT   Condition: [ST]
FT   BINDING         232
FT                   /ligand="5-amino-1-(5-phospho-beta-D-
FT                   ribosyl)imidazole-4-carboxamide"
FT                   /ligand_id="ChEBI:CHEBI:58475"
FT   Condition: N
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Size: 330-377;
Related: None;
Template: Q57600; Q8U0R7;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in METMA
Plasmid: None
Comments: None
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# Revision 1.21 2022/11/19
//