AC   MF_01167;
DC   Protein; auto
TR   HAMAP; MF_01167; -; 1; level=0
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Names: ArnB_transfer
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ID   ARNB
DE   RecName: Full=UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase;
DE            EC=2.6.1.87;
DE   AltName: Full=UDP-4-amino-4-deoxy-L-arabinose aminotransferase;
DE   AltName: Full=UDP-(beta-L-threo-pentapyranosyl-4''-ulose diphosphate) aminotransferase;
DE            Short=UDP-Ara4O aminotransferase;
GN   Name=arnB;
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CC   -!- FUNCTION: Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O)
CC       to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified
CC       arabinose is attached to lipid A and is required for resistance to
CC       polymyxin and cationic antimicrobial peptides.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + UDP-4-amino-4-deoxy-beta-L-arabinose = L-
CC         glutamate + UDP-beta-L-threo-pentopyranos-4-ulose;
CC         Xref=Rhea:RHEA:24710, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:58708, ChEBI:CHEBI:58710; EC=2.6.1.87;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-4-deoxy-4-formamido-beta-L-
CC       arabinose biosynthesis; UDP-4-deoxy-4-formamido-beta-L-arabinose from
CC       UDP-alpha-D-glucuronate: step 2/3.
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily.
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DR   Pfam; PF01041; DegT_DnrJ_EryC1; 1; trigger=no
DR   PIRSF; PIRSF000390; PLP_StrS; 1; trigger=no
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KW   Aminotransferase
KW   Antibiotic resistance
KW   Lipid A biosynthesis
KW   Lipid biosynthesis
KW   Lipid metabolism
KW   Lipopolysaccharide biosynthesis
KW   Pyridoxal phosphate
KW   Transferase
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GO   GO:0008483; F:transaminase activity
GO   GO:0046493; P:lipid A metabolic process
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FT   From: ARNB_SALTY (Q8ZNF3)
FT   MOD_RES         188
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT   Condition: K
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Size: 378-388;
Related: None;
Template: Q8ZNF3; P77690;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.27 2019/11/19
//