AC   MF_01169;
DC   Protein; auto
TR   HAMAP; MF_01169; -; 1; level=0
XX
Names: SucA_OdhA
XX
ID   ODO1
DE   RecName: Full=2-oxoglutarate dehydrogenase E1 component;
DE            EC=1.2.4.2;
DE   AltName: Full=Alpha-ketoglutarate dehydrogenase;
case <OC:Bacillota>
GN   Name=odhA;
end case
case not <OC:Bacillota>
GN   Name=sucA; Synonyms=odhA;
end case
XX
CC   -!- FUNCTION: E1 component of the 2-oxoglutarate dehydrogenase (OGDH)
CC       complex which catalyzes the decarboxylation of 2-oxoglutarate, the
CC       first step in the conversion of 2-oxoglutarate to succinyl-CoA and
CC       CO(2).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + H(+) + N(6)-[(R)-lipoyl]-L-lysyl-
CC         [dihydrolipoyllysine-residue succinyltransferase] = CO2 + N(6)-[(R)-
CC         S(8)-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue
CC         succinyltransferase]; Xref=Rhea:RHEA:12188, Rhea:RHEA-COMP:10483,
CC         Rhea:RHEA-COMP:10484, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:83099, ChEBI:CHEBI:83120; EC=1.2.4.2;
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC   -!- SUBUNIT: Homodimer. Part of the 2-oxoglutarate dehydrogenase (OGDH)
CC       complex composed of E1 (2-oxoglutarate dehydrogenase), E2
CC       (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide
CC       dehydrogenase); the complex contains multiple copies of the three
CC       enzymatic components (E1, E2 and E3).
CC   -!- SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.
XX
DR   Pfam; PF00676; E1_dh; 1; trigger=no
DR   Pfam; PF02779; Transket_pyr; 1; trigger=no
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1; trigger=no
XX
KW   Glycolysis
KW   Oxidoreductase
KW   Thiamine pyrophosphate
XX
GO   GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity
GO   GO:0030976; F:thiamine pyrophosphate binding
GO   GO:0006096; P:glycolytic process
XX
Size: 910-1004;
Related: None;
Template: P23129;
Scope:
 Bacteria; Bacillales
 Bacteria; Brucellaceae
 Bacteria; Leptospiraceae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: This family is restricted taxonomically to some bacteria so as to avoid
 overlap with proteins that have similarity to alpha-ketoglutarate dehydrogenase
 but may be a different enzyme.
XX
# Revision 1.17 2023/09/14
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