AC   MF_01179;
DC   Protein; auto
TR   HAMAP; MF_01179; -; 1; level=0
XX
Names: SulA
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ID   SULA
DE   RecName: Full=Cell division inhibitor SulA;
GN   Name=sulA;
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CC   -!- FUNCTION: Component of the SOS system and an inhibitor of cell
CC       division. Accumulation of SulA causes rapid cessation of cell division
CC       and the appearance of long, non-septate filaments. In the presence of
CC       GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus
CC       inhibiting FtsZ polymerization and therefore preventing it from
CC       participating in the assembly of the Z ring. This mechanism prevents
CC       the premature segregation of damaged DNA to daughter cells during cell
CC       division.
CC   -!- SUBUNIT: Interacts with FtsZ.
CC   -!- INDUCTION: By DNA damage, as part of the SOS response.
CC   -!- PTM: Is rapidly cleaved and degraded by the Lon protease once DNA
CC       damage is repaired.
CC   -!- SIMILARITY: Belongs to the SulA family.
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DR   Pfam; PF03846; SulA; 1; trigger=no
DR   NCBIfam; TIGR00623; Sula; 1; trigger=no
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KW   Cell cycle
KW   Cell division
KW   DNA damage
KW   Septation
KW   SOS response
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GO   GO:0051782; P:negative regulation of cell division
GO   GO:0006974; P:DNA damage response
GO   GO:0009432; P:SOS response
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FT   From: SULA_ECOLI (P0AFZ5)
FT   REGION          106..112
FT                   /note="FtsZ binding"
FT   Condition: A-L-x-[TS]-G-N-Y
FT   REGION          162..169
FT                   /note="Lon protease binding"
FT   Condition: [KR]-I-H-S-x-x-x-H
FT   SITE            169
FT                   /note="Essential for degradation by Lon protease"
FT   Condition: H
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Size: 168-177;
Related: None;
Template: P0AFZ5; Q9HZJ8;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Due to the high divergence of SulA sequences, this family includes
 only members from the Enterobacterales. There is a 3D-structure available for SulA
 from Pseudomonas aeruginosa; this protein is not a member of this family though it
 probably has the same function; the information derived from the structure was included
 in this rule.
 It is not clear whether SulA is located in the cytoplasm or is inner-membrane associated.
 The sulA gene is interrupted by an insertion sequence in Shigella dysenteriae serotype 1
 (strain Sd197).
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# Revision 1.14 2023/06/01
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