AC   MF_01184;
DC   Protein; auto
TR   HAMAP; MF_01184; -; 1; level=0
XX
Names: XPRTase
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ID   XPT
DE   RecName: Full=Xanthine phosphoribosyltransferase;
DE            Short=XPRTase;
DE            EC=2.4.2.22;
GN   Name=xpt;
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CC   -!- FUNCTION: Converts the preformed base xanthine, a product of nucleic
CC       acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be
CC       reused for RNA or DNA synthesis.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + XMP = 5-phospho-alpha-D-ribose 1-diphosphate +
CC         xanthine; Xref=Rhea:RHEA:10800, ChEBI:CHEBI:17712, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57464, ChEBI:CHEBI:58017; EC=2.4.2.22;
CC   -!- PATHWAY: Purine metabolism; XMP biosynthesis via salvage pathway; XMP
CC       from xanthine: step 1/1.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. Xpt subfamily.
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DR   PROSITE; PS00103; PUR_PYR_PR_TRANSFER; 1; trigger=no
DR   Pfam; PF00156; Pribosyltran; 1; trigger=no
DR   NCBIfam; TIGR01744; XPRTase; 1; trigger=no
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KW   Cytoplasm
KW   Glycosyltransferase
KW   Purine salvage
KW   Transferase
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GO   GO:0000310; F:xanthine phosphoribosyltransferase activity
GO   GO:0006166; P:purine ribonucleoside salvage
GO   GO:0005737; C:cytoplasm
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FT   From: XPT_BACSU (P42085)
FT   BINDING         128..132
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT   BINDING         20
FT                   /ligand="xanthine"
FT                   /ligand_id="ChEBI:CHEBI:17712"
FT   Condition: L
FT   BINDING         27
FT                   /ligand="xanthine"
FT                   /ligand_id="ChEBI:CHEBI:17712"
FT   Condition: [NT]
FT   BINDING         156
FT                   /ligand="xanthine"
FT                   /ligand_id="ChEBI:CHEBI:17712"
FT   Condition: K
XX
Size: 188-211;
Related: None;
Template: P42085;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in CLOB1, CLOBH, CLOBL, CLOP1, CLOPE, CLOPS
Plasmid: None
Comments: None
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# Revision 1.19 2023/06/01
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