AC   MF_01189;
DC   Protein; auto
TR   HAMAP; MF_01189; -; 1; level=0
XX
Names: MFS_NepI
XX
ID   NEPI
DE   RecName: Full=Purine ribonucleoside efflux pump NepI;
GN   Name=nepI;
XX
CC   -!- FUNCTION: Involved in the efflux of purine ribonucleosides, such as
CC       inosine and guanosine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(out) + inosine(in) = H(+)(in) + inosine(out);
CC         Xref=Rhea:RHEA:29211, ChEBI:CHEBI:15378, ChEBI:CHEBI:17596;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29212;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(in) + H(+)(out) = guanosine(out) + H(+)(in);
CC         Xref=Rhea:RHEA:29583, ChEBI:CHEBI:15378, ChEBI:CHEBI:16750;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29584;
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. DHA1 family.
CC       NepI (TC 2.A.1.2.26) subfamily.
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DR   PROSITE; PS50850; MFS; 1; trigger=no
DR   Pfam; PF07690; MFS_1; 1; trigger=no
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KW   Antiport
KW   Cell membrane
KW   Cell inner membrane
KW   Membrane
KW   Transmembrane
KW   Transport
KW   Transmembrane helix
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GO   GO:0015211; F:purine nucleoside transmembrane transporter activity
GO   GO:0005886; C:plasma membrane
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FT   From: NEPI_ECOLI (P0ADL1)
FT   TOPO_DOM        Nter..21
FT                   /note="Cytoplasmic"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT   TOPO_DOM        43..54
FT                   /note="Periplasmic"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT   TOPO_DOM        76..85
FT                   /note="Cytoplasmic"
FT   TRANSMEM        86..106
FT                   /note="Helical"
FT   TOPO_DOM        107
FT                   /note="Periplasmic"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT   TOPO_DOM        129..147
FT                   /note="Cytoplasmic"
FT   TRANSMEM        148..168
FT                   /note="Helical"
FT   TOPO_DOM        169..175
FT                   /note="Periplasmic"
FT   TRANSMEM        176..196
FT                   /note="Helical"
FT   TOPO_DOM        197..215
FT                   /note="Cytoplasmic"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT   TOPO_DOM        237..255
FT                   /note="Periplasmic"
FT   TRANSMEM        256..276
FT                   /note="Helical"
FT   TOPO_DOM        277..281
FT                   /note="Cytoplasmic"
FT   TRANSMEM        282..302
FT                   /note="Helical"
FT   TOPO_DOM        303..305
FT                   /note="Periplasmic"
FT   TRANSMEM        306..326
FT                   /note="Helical"
FT   TOPO_DOM        327..343
FT                   /note="Cytoplasmic"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT   TOPO_DOM        365..366
FT                   /note="Periplasmic"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT   TOPO_DOM        388..Cter
FT                   /note="Cytoplasmic"
XX
Size: 390-455;
Related: None;
Template: P0ADL1;
Scope:
 Bacteria; Enterobacteriaceae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.18 2022/09/29
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