AC   MF_01195;
DC   Protein; auto
TR   HAMAP; MF_01195; -; 1; level=0
XX
Names: NanM
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ID   NANM
DE   RecName: Full=N-acetylneuraminate epimerase;
DE            EC=5.1.3.24;
DE   AltName: Full=N-acetylneuraminate mutarotase;
DE            Short=Neu5Ac mutarotase;
DE   AltName: Full=Sialic acid epimerase;
DE   Flags: Precursor;
GN   Name=nanM;
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CC   -!- FUNCTION: Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-
CC       anomer, accelerating the equilibrium between the alpha- and beta-
CC       anomers. Probably facilitates sialidase-negative bacteria to compete
CC       sucessfully for limited amounts of extracellular Neu5Ac, which is
CC       likely taken up in the beta-anomer. In addition, the rapid removal of
CC       sialic acid from solution might be advantageous to the bacterium to
CC       damp down host responses.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-acetyl-alpha-neuraminate = N-acetyl-beta-neuraminate;
CC         Xref=Rhea:RHEA:25233, ChEBI:CHEBI:58705, ChEBI:CHEBI:58770;
CC         EC=5.1.3.24;
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the NanM family.
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DR   Pfam; PF01344; Kelch_1; 1; trigger=no
DR   NCBIfam; TIGR03547; Muta_rot_YjhT; 1; trigger=no
DR   General; Signal; -; 1; trigger=yes
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KW   Carbohydrate metabolism
KW   Isomerase
KW   Kelch repeat
KW   Periplasm
KW   Repeat
KW   Signal
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GO   GO:0016857; F:racemase and epimerase activity, acting on carbohydrates and derivatives
GO   GO:0042597; C:periplasmic space
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FT   From: NANM_ECOLI (P39371)
FT   REPEAT          40..84
FT                   /note="Kelch 1"
FT   REPEAT          86..137
FT                   /note="Kelch 2"
FT   REPEAT          139..173
FT                   /note="Kelch 3"
FT   REPEAT          174..219
FT                   /note="Kelch 4"
FT   REPEAT          222..265
FT                   /note="Kelch 5"
FT   REPEAT          287..336
FT                   /note="Kelch 6"
FT   REPEAT          338..367
FT                   /note="Kelch 7"
FT   ACT_SITE        228
FT                   /note="Proton acceptor"
FT   Condition: E
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Size: 368-392;
Related: None;
Template: P39371;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: in ECOL6
Plasmid: None
Comments: None
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# Revision 1.17 2023/06/01
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