AC   MF_01208;
DC   Protein; auto
TR   HAMAP; MF_01208; -; 1; level=0
XX
Names: PyrE
XX
ID   PYRE
DE   RecName: Full=Orotate phosphoribosyltransferase;
DE            Short=OPRT;
DE            Short=OPRTase;
DE            EC=2.4.2.10;
GN   Name=pyrE;
XX
CC   -!- FUNCTION: Catalyzes the transfer of a ribosyl phosphate group from 5-
CC       phosphoribose 1-diphosphate to orotate, leading to the formation of
CC       orotidine monophosphate (OMP).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-
CC         ribose 1-diphosphate + orotate; Xref=Rhea:RHEA:10380,
CC         ChEBI:CHEBI:30839, ChEBI:CHEBI:33019, ChEBI:CHEBI:57538,
CC         ChEBI:CHEBI:58017; EC=2.4.2.10;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       UMP from orotate: step 1/2.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. PyrE subfamily.
XX
DR   Pfam; PF00156; Pribosyltran; 1; trigger=no
DR   NCBIfam; TIGR00336; PyrE; 1; trigger=no
DR   NCBIfam; TIGR01367; PyrE_Therm; 1; trigger=no
DR   PROSITE; PS00103; PUR_PYR_PR_TRANSFER; 1; trigger=no
XX
KW   Pyrimidine biosynthesis
KW   Transferase
KW   Glycosyltransferase
KW   Magnesium
XX
GO   GO:0000287; F:magnesium ion binding
GO   GO:0004588; F:orotate phosphoribosyltransferase activity
GO   GO:0006221; P:pyrimidine nucleotide biosynthetic process
XX
FT   From: PYRE_SALTY (P08870)
case <OC:Bacteria>
FT   BINDING         34..35
FT                   /ligand="orotate"
FT                   /ligand_id="ChEBI:CHEBI:30839"
FT   Optional; Condition: F-F
FT   BINDING         72..73
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT   Optional; Condition: Y-K
FT   BINDING         124..132
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT   BINDING         26
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT   Optional; Condition: [KR]
FT   BINDING         99
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /ligand_note="ligand shared between dimeric partners"
FT   Optional; Condition: R
FT   BINDING         100
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT   Optional; Condition: K
FT   BINDING         103
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /ligand_note="ligand shared between dimeric partners"
FT   Optional; Condition: K
FT   BINDING         105
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /ligand_note="ligand shared between dimeric partners"
FT   Optional; Condition: H
FT   BINDING         128
FT                   /ligand="orotate"
FT                   /ligand_id="ChEBI:CHEBI:30839"
FT   Optional; Condition: [ST]
FT   BINDING         156
FT                   /ligand="orotate"
FT                   /ligand_id="ChEBI:CHEBI:30839"
FT   Optional; Condition: R
end case
FT   From: PYRE_PYRHO (O58855)
case <OC:Archaea>
FT   BINDING         119..127
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT   BINDING         93
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /ligand_note="ligand shared between dimeric partners"
FT   Optional; Condition: R
FT   BINDING         94
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT   Optional; Condition: K
FT   BINDING         97
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /ligand_note="ligand shared between dimeric partners"
FT   Optional; Condition: [KR]
FT   BINDING         99
FT                   /ligand="5-phospho-alpha-D-ribose 1-diphosphate"
FT                   /ligand_id="ChEBI:CHEBI:58017"
FT                   /ligand_note="ligand shared between dimeric partners"
FT   Optional; Condition: H
FT   BINDING         123
FT                   /ligand="orotate"
FT                   /ligand_id="ChEBI:CHEBI:30839"
FT   Optional; Condition: T
FT   BINDING         151
FT                   /ligand="orotate"
FT                   /ligand_id="ChEBI:CHEBI:30839"
FT   Optional; Condition: R
end case
XX
Size: 166-237;
Related: MF_01214;
Template: P0A7E3; P08870; P42719; P61498; P46534;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: MF_01200 (pyrF)
 Cter: None
Duplicate: in NOSS1, RHILO
Plasmid: None
Comments: None
XX
# Revision 1.37 2023/06/01
//