AC   MF_01215;
DC   Protein; auto
TR   HAMAP; MF_01215; -; 1; level=0
XX
Names: OMPdecase_type2
XX
ID   PYRF
DE   RecName: Full=Orotidine 5'-phosphate decarboxylase;
DE            EC=4.1.1.23;
DE   AltName: Full=OMP decarboxylase;
DE            Short=OMPDCase;
DE            Short=OMPdecase;
GN   Name=pyrF;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + orotidine 5'-phosphate = CO2 + UMP;
CC         Xref=Rhea:RHEA:11596, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:57538, ChEBI:CHEBI:57865; EC=4.1.1.23;
CC   -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway;
CC       UMP from orotate: step 2/2.
CC   -!- SIMILARITY: Belongs to the OMP decarboxylase family. Type 2 subfamily.
XX
DR   Pfam; PF00215; OMPdecase; 1; trigger=no
DR   PROSITE; PS00156; OMPDECASE; 1; trigger=no
DR   NCBIfam; TIGR02127; pyrF_sub2; 1; trigger=no
XX
KW   Lyase
KW   Decarboxylase
KW   Pyrimidine biosynthesis
XX
GO   GO:0004590; F:orotidine-5'-phosphate decarboxylase activity
GO   GO:0006221; P:pyrimidine nucleotide biosynthetic process
XX
FT   From: PYRF_DEIRA (Q9RSC5)
FT   ACT_SITE        92
FT                   /note="Proton donor"
FT   Condition: K
XX
Size: 267-307;
Related: MF_01200;
Template: P0A5M7; P96076;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: MF_01208 (pyrE)
Duplicate: None
Plasmid: None
Comments: Divergent NOSS1; sequence not included in alignment
XX
# Revision 1.26 2023/06/01
//