AC   MF_01219;
DC   Protein; auto
TR   HAMAP; MF_01219; -; 1; level=0
XX
Names: PyrR
XX
ID   PYRR
DE   RecName: Full=Bifunctional protein PyrR;
DE   Includes:
DE     RecName: Full=Pyrimidine operon regulatory protein;
DE   Includes:
DE     RecName: Full=Uracil phosphoribosyltransferase;
DE              Short=UPRTase;
DE              EC=2.4.2.9;
GN   Name=pyrR;
XX
case <OC:Bacillota>
CC   -!- FUNCTION: Regulates transcriptional attenuation of the pyrimidine
CC       nucleotide (pyr) operon by binding in a uridine-dependent manner to
CC       specific sites on pyr mRNA. This disrupts an antiterminator hairpin in
CC       the RNA and favors formation of a downstream transcription terminator,
CC       leading to a reduced expression of downstream genes.
end case
case not <OC:Bacillota>
CC   -!- FUNCTION: Regulates the transcription of the pyrimidine nucleotide
CC       (pyr) operon in response to exogenous pyrimidines.
end case
CC   -!- FUNCTION: Also displays a weak uracil phosphoribosyltransferase
CC       activity which is not physiologically significant.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate +
CC         uracil; Xref=Rhea:RHEA:13017, ChEBI:CHEBI:17568, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57865, ChEBI:CHEBI:58017; EC=2.4.2.9;
case <OC:Bacillota>
CC   -!- SUBUNIT: Homodimer and homohexamer; in equilibrium.
end case
CC   -!- SIMILARITY: Belongs to the purine/pyrimidine phosphoribosyltransferase
CC       family. PyrR subfamily.
XX
DR   Pfam; PF00156; Pribosyltran; 1; trigger=no
DR   PROSITE; PS00103; PUR_PYR_PR_TRANSFER; 1; trigger=no
XX
KW   Transcription
case <OC:Bacillota>
KW   Transcription regulation
KW   Transcription termination
KW   RNA-binding
end case
case not <OC:Bacillota>
KW   Transcription regulation
end case
KW   Transferase
KW   Glycosyltransferase
XX
case <OC:Bacillota>
GO   GO:0003723; F:RNA binding
end case
GO   GO:0004845; F:uracil phosphoribosyltransferase activity
case not <OC:Bacillota>
GO   GO:0006355; P:regulation of DNA-templated transcription
end case
case <OC:Bacillota>
GO   GO:0006353; P:DNA-templated transcription termination
end case
XX
FT   From: PYRR_BACSU (P39765)
FT   MOTIF           101..113
FT                   /note="PRPP-binding"
XX
Size: 168-193;
Related: None;
Template: P39765; P41007; F2MMP6;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in LACPL
Plasmid: None
Comments: None
XX
# Revision 1.28 2023/01/13
//