AC   MF_01234;
DC   Protein; auto
TR   HAMAP; MF_01234; -; 1; level=0
XX
Names: ManNAc_kinase
XX
ID   NANK
DE   RecName: Full=N-acetylmannosamine kinase;
DE            EC=2.7.1.60;
DE   AltName: Full=ManNAc kinase;
DE   AltName: Full=N-acetyl-D-mannosamine kinase;
GN   Name=nanK;
XX
CC   -!- FUNCTION: Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc)
CC       to ManNAc-6-P.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acyl-D-mannosamine + ATP = ADP + an N-acyl-D-mannosamine
CC         6-phosphate + H(+); Xref=Rhea:RHEA:23832, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16062, ChEBI:CHEBI:30616, ChEBI:CHEBI:57666,
CC         ChEBI:CHEBI:456216; EC=2.7.1.60;
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation; D-
CC       fructose 6-phosphate from N-acetylneuraminate: step 2/5.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the ROK (NagC/XylR) family. NanK subfamily.
XX
DR   Pfam; PF00480; ROK; 1; trigger=no
DR   PROSITE; PS01125; ROK; 1; trigger=no
XX
KW   Carbohydrate metabolism
KW   Transferase
KW   Kinase
KW   ATP-binding
KW   Nucleotide-binding
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0005524; F:ATP binding
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
GO   GO:0009384; F:N-acylmannosamine kinase activity
GO   GO:0005975; P:carbohydrate metabolic process
GO   GO:0006051; P:N-acetylmannosamine metabolic process
XX
FT   From: NANK_ECOLI (P45425)
FT   BINDING         5..12
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   BINDING         132..139
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   BINDING         156
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: H
FT   BINDING         166
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         168
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         173
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
XX
Size: 287-300;
Related: None;
Template: P45425;
Scope:
 Bacteria
Fusion:
 Nter: MF_01235 (nanE)
 Cter: None
Duplicate: in ECOL6
Plasmid: None
Comments: None
XX
# Revision 1.27 2022/11/19
//