AC   MF_01235;
DC   Protein; auto
TR   HAMAP; MF_01235; -; 1; level=0
XX
Names: ManNAc6P_epimer
XX
ID   NANE
DE   RecName: Full=N-acetylmannosamine-6-phosphate 2-epimerase;
DE            EC=5.1.3.9;
DE   AltName: Full=ManNAc-6-P epimerase;
GN   Name=nanE;
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CC   -!- FUNCTION: Epimerase involved in the degradation of sialic acid.
CC       Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-
CC       acetylglucosamine-6-phosphate (GlcNAc-6-P).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an N-acyl-D-glucosamine 6-phosphate = an N-acyl-D-mannosamine
CC         6-phosphate; Xref=Rhea:RHEA:23932, ChEBI:CHEBI:57599,
CC         ChEBI:CHEBI:57666; EC=5.1.3.9;
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:23934; Evidence=;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-acetyl-D-glucosamine 6-phosphate = aldehydo-N-acetyl-D-
CC         mannosamine 6-phosphate; Xref=Rhea:RHEA:25257, ChEBI:CHEBI:57513,
CC         ChEBI:CHEBI:58557; EC=5.1.3.9;
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:25259; Evidence=;
CC   -!- PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation; D-
CC       fructose 6-phosphate from N-acetylneuraminate: step 3/5.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the NanE family.
XX
DR   Pfam; PF04131; NanE; 1; trigger=no
DR   NCBIfam; NF002231; PRK01130.1; 1; trigger=no
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KW   Carbohydrate metabolism
KW   Isomerase
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GO   GO:0016857; F:racemase and epimerase activity, acting on carbohydrates and derivatives
GO   GO:0005975; P:carbohydrate metabolic process
GO   GO:0019262; P:N-acetylneuraminate catabolic process
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FT   From: NANE_STAA3 (Q2FJU6)
FT   ACT_SITE        63
FT                   /note="Proton acceptor"
FT   Condition: K
FT   ACT_SITE        180
FT                   /note="Proton donor"
FT   Condition: E
FT   BINDING         11
FT                   /ligand="aldehydo-N-acetyl-D-mannosamine 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58557"
FT   Optional; Condition: Q
FT   BINDING         40
FT                   /ligand="aldehydo-N-acetyl-D-mannosamine 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58557"
FT   Optional; Condition: R
FT   BINDING         180
FT                   /ligand="aldehydo-N-acetyl-D-mannosamine 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58557"
FT   Optional; Condition: E
FT   BINDING         182
FT                   /ligand="aldehydo-N-acetyl-D-mannosamine 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58557"
FT   Optional; Condition: [NRK]
FT   BINDING         203
FT                   /ligand="aldehydo-N-acetyl-D-mannosamine 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58557"
FT   Optional; Condition: G
FT   BINDING         204
FT                   /ligand="aldehydo-N-acetyl-D-mannosamine 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58557"
FT   Optional; Condition: [GS]
FT   BINDING         208
FT                   /ligand="aldehydo-N-acetyl-D-mannosamine 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58557"
FT   Optional; Condition: R
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Size: 221-240;
Related: None;
Template: Q2FJU6; Q8XNZ3; Q8RDN5; Q9KR62; P0A761;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: MF_01234 (nanK)
Duplicate: in SALTY, STRPN, STRR6
Plasmid: None
Comments: None
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# Version: 19
# Last updated date: 2025-11-20
# Created date: 2005-02-28
//