AC   MF_01257;
DC   Protein; auto
TR   HAMAP; MF_01257; -; 1; level=0
XX
Names: CofD
XX
case <OC:Actinomycetota>
ID   FBIA
DE   RecName: Full=Phosphoenolpyruvate transferase;
DE            EC=2.7.8.28;
DE   AltName: Full=EPPG:FO PEP transferase;
GN   Name=fbiA;
else case <OC:Archaea>
ID   COFD
DE   RecName: Full=2-phospho-L-lactate transferase;
DE            EC=2.7.8.28;
DE   AltName: Full=EPPG:FO PEP transferase;
GN   Name=cofD;
end case
XX
case <OC:Actinomycetota>
CC   -!- FUNCTION: Catalyzes the transfer of the phosphoenolpyruvate moiety from
CC       enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-
CC       hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme
CC       F420-0 and GMP.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7,8-didemethyl-8-hydroxy-5-deazariboflavin + enolpyruvoyl-2-
CC         diphospho-5'-guanosine = dehydro coenzyme F420-0 + GMP + H(+);
CC         Xref=Rhea:RHEA:27510, ChEBI:CHEBI:15378, ChEBI:CHEBI:58115,
CC         ChEBI:CHEBI:59904, ChEBI:CHEBI:143701, ChEBI:CHEBI:143705;
CC         EC=2.7.8.28;
else case <OC:Archaea>
CC   -!- FUNCTION: Catalyzes the transfer of the 2-phospholactate moiety from
CC       (2S)-lactyl-2-diphospho-5'-guanosine to 7,8-didemethyl-8-hydroxy-5-
CC       deazariboflavin (FO) with the formation of oxidized coenzyme F420-0 and
CC       GMP.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2S)-lactyl-2-diphospho-5'-guanosine + 7,8-didemethyl-8-
CC         hydroxy-5-deazariboflavin = GMP + H(+) + oxidized coenzyme F420-0;
CC         Xref=Rhea:RHEA:63444, ChEBI:CHEBI:15378, ChEBI:CHEBI:58115,
CC         ChEBI:CHEBI:59435, ChEBI:CHEBI:59904, ChEBI:CHEBI:59907; EC=2.7.8.28;
end case
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the CofD family.
XX
DR   Pfam; PF01933; UPF0052; 1; trigger=no
DR   NCBIfam; TIGR01819; F420_cofD; 1; trigger=no
XX
KW   Magnesium
KW   Transferase
XX
GO   GO:0016773; F:phosphotransferase activity, alcohol group as acceptor
GO   GO:0052645; P:F420-0 metabolic process
XX
FT   From: COFD_METMA (Q8PVT6)
FT   BINDING         48
FT                   /ligand="7,8-didemethyl-8-hydroxy-5-deazariboflavin"
FT                   /ligand_id="ChEBI:CHEBI:59904"
FT   Condition: D
FT   BINDING         87
FT                   /ligand="7,8-didemethyl-8-hydroxy-5-deazariboflavin"
FT                   /ligand_id="ChEBI:CHEBI:59904"
FT   Optional; Condition: [KR]
XX
Size: 296-337;
Related: None;
Template: P9WP81; Q8PVT6; Q58653;
Scope:
 Bacteria; Mycobacterium
 Bacteria; Nocardia
 Bacteria; Streptomyces
 Archaea; Archaeoglobi
 Archaea; Halobacteria
 Archaea; Methanobacteria
 Archaea; Methanococci
 Archaea; Methanomicrobia
 Archaea; Methanopyri
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: CofD homologs are found in the genomes of all organisms currently known to
 produce coenzyme F420. These include not only the methanogenic archaea but
 also nonmethanogenic archaea such as Halobacteria and Archaeoglobus, as well
 as some eubacteria such as Streptomyces, Mycobacterium, Nocardia, and
 Thermobifida.
 The reaction was shown to be different according to the species, but IUBMB has created a single
 EC number (they consider it is the same enzyme).
XX
# Revision 1.20 2023/06/01
//