AC   MF_01273;
DC   Protein; auto
TR   HAMAP; MF_01273; -; 1; level=0
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Names: Pantothen_kinase_2
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ID   COAW
DE   RecName: Full=Type II pantothenate kinase;
DE            EC=2.7.1.33;
DE   AltName: Full=PanK-II;
DE   AltName: Full=Pantothenic acid kinase;
GN   Name=coaW;
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CC   -!- FUNCTION: Catalyzes the phosphorylation of pantothenate (Pan), the
CC       first step in CoA biosynthesis.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP +
CC         H(+); Xref=Rhea:RHEA:16373, ChEBI:CHEBI:10986, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29032, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216;
CC         EC=2.7.1.33;
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-
CC       pantothenate: step 1/5.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the type II pantothenate kinase family.
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DR   Pfam; PF03630; Fumble; 1; trigger=no
DR   NCBIfam; TIGR00555; PanK_eukar; 1; trigger=no
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KW   Cytoplasm
KW   ATP-binding
KW   Coenzyme A biosynthesis
KW   Kinase
KW   Nucleotide-binding
KW   Transferase
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GO   GO:0005524; F:ATP binding
GO   GO:0004594; F:pantothenate kinase activity
GO   GO:0015937; P:coenzyme A biosynthetic process
GO   GO:0005737; C:cytoplasm
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FT   From: COAW_STAAS (Q6G7I0)
FT   BINDING         6..13
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   BINDING         121..125
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   ACT_SITE        70
FT                   /note="Proton acceptor"
FT   Condition: E
FT   BINDING         99
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: T
FT   BINDING         137
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [YF]
FT   BINDING         225
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: S
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Size: 262-276;
Related: None;
Template: Q2FWC7; Q6G7I0;
Scope:
 Bacteria; Bacillota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: There are three distinct types of pantothenate kinase, as differenciated
 by primary sequence analysis and biochemical properties: type I (MF_00215),
 type II (MF_01273) and type III (MF_01274).
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# Revision 1.18 2023/06/01
//