AC   MF_01276;
DC   Protein; auto
TR   HAMAP; MF_01276; -; 1; level=0
XX
Names: Putres_aminotrans_3
XX
ID   PAT
DE   RecName: Full=Putrescine aminotransferase;
DE            Short=PAT;
DE            Short=PATase;
DE            EC=2.6.1.82;
DE   AltName: Full=Cadaverine transaminase;
DE   AltName: Full=Diamine transaminase;
DE            EC=2.6.1.29;
DE   AltName: Full=Putrescine transaminase;
DE   AltName: Full=Putrescine--2-oxoglutaric acid transaminase;
GN   Name=patA;
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CC   -!- FUNCTION: Catalyzes the aminotransferase reaction from putrescine to 2-
CC       oxoglutarate, leading to glutamate and 4-aminobutanal, which
CC       spontaneously cyclizes to form 1-pyrroline. This is the first step in
CC       one of two pathways for putrescine degradation, where putrescine is
CC       converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4-
CC       aminobutanal. Also functions as a cadaverine transaminase in a a L-
CC       lysine degradation pathway to succinate that proceeds via cadaverine,
CC       glutarate and L-2-hydroxyglutarate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + an alkane-alpha,omega-diamine = an omega-
CC         aminoaldehyde + L-glutamate; Xref=Rhea:RHEA:18217, Rhea:RHEA-
CC         COMP:9766, Rhea:RHEA-COMP:12750, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:70977, ChEBI:CHEBI:133427;
CC         EC=2.6.1.29;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:18218;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + putrescine = 1-pyrroline + H2O + L-glutamate;
CC         Xref=Rhea:RHEA:12268, ChEBI:CHEBI:15377, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:29985, ChEBI:CHEBI:36781, ChEBI:CHEBI:326268;
CC         EC=2.6.1.82;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:12269;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + cadaverine = 5-aminopentanal + L-glutamate;
CC         Xref=Rhea:RHEA:61624, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:58384, ChEBI:CHEBI:144896;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61625;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC   -!- PATHWAY: Amine and polyamine degradation; putrescine degradation; 4-
CC       aminobutanal from putrescine (transaminase route): step 1/1.
CC   -!- PATHWAY: Amino-acid degradation.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the class-III pyridoxal-phosphate-dependent
CC       aminotransferase family. Putrescine aminotransferase subfamily.
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DR   PROSITE; PS00600; AA_TRANSFER_CLASS_3; 1; trigger=no
DR   Pfam; PF00202; Aminotran_3; 1; trigger=no
DR   NCBIfam; TIGR03372; putres_am_tran; 1; trigger=no
DR   PIRSF; PIRSF000521; Transaminase_4ab_Lys_Orn; 1; trigger=no
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KW   Aminotransferase
KW   Pyridoxal phosphate
KW   Transferase
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GO   GO:0033094; F:putrescine--2-oxoglutarate transaminase activity
GO   GO:0030170; F:pyridoxal phosphate binding
GO   GO:0009447; P:putrescine catabolic process
GO   GO:0019477; P:L-lysine catabolic process
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FT   From: PAT_ECOLI (P42588)
FT   BINDING         150..151
FT                   /ligand="pyridoxal 5'-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:597326"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT   Condition: G-T
FT   BINDING         274
FT                   /ligand="pyridoxal 5'-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:597326"
FT                   /ligand_note="ligand shared between dimeric partners"
FT                   /note="in other chain"
FT   Condition: Q
FT   BINDING         332
FT                   /ligand="pyridoxal 5'-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:597326"
FT                   /ligand_note="ligand shared between dimeric partners"
FT   Condition: T
FT   MOD_RES         300
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT   Condition: K
XX
Size: 459-468;
Related: None;
Template: P42588;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.23 2023/10/13
//