AC   MF_01277;
DC   Protein; auto
TR   HAMAP; MF_01277; -; 1; level=0
XX
Names: HTH_type_PurR
XX
ID   PURR
DE   RecName: Full=HTH-type transcriptional repressor PurR;
DE   AltName: Full=Pur regulon repressor;
DE   AltName: Full=Purine nucleotide synthesis repressor;
GN   Name=purR;
XX
CC   -!- FUNCTION: Is the main repressor of the genes involved in the de novo
CC       synthesis of purine nucleotides, regulating purB, purC, purEK, purF,
CC       purHD, purL, purMN and guaBA expression. PurR is allosterically
CC       activated to bind its cognate DNA by binding the purine corepressors,
CC       hypoxanthine or guanine, thereby effecting transcription repression.
CC   -!- PATHWAY: Purine metabolism; purine nucleotide biosynthesis
CC       [regulation].
CC   -!- SUBUNIT: Homodimer.
CC   -!- DOMAIN: Consists of two structural and functional domains: an N-
CC       terminal DNA-binding domain, approximately the first 60 residues, and a
CC       larger C-terminal domain, approximately 280 residues, which imparts the
CC       function of corepressor binding and oligomerization.
XX
DR   PROSITE; PS00356; HTH_LACI_1; 1; trigger=no
DR   PROSITE; PS50932; HTH_LACI_2; 1; trigger=yes
DR   Pfam; PF00356; LacI; 1; trigger=no
DR   Pfam; PF00532; Peripla_BP_1; 1; trigger=no
DR   PRINTS; PR00036; HTHLACI; 1; trigger=no
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KW   DNA-binding
KW   Purine biosynthesis
KW   Repressor
KW   Transcription
KW   Transcription regulation
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GO   GO:0045892; P:negative regulation of DNA-templated transcription
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FT   From: PURR_ECOLI (P0ACP7)
FT   DNA_BIND        4..23
FT                   /note="H-T-H motif"
FT   DNA_BIND        48..56
FT   BINDING         73
FT                   /ligand="hypoxanthine"
FT                   /ligand_id="ChEBI:CHEBI:17368"
FT   Condition: [YF]
FT   BINDING         190
FT                   /ligand="hypoxanthine"
FT                   /ligand_id="ChEBI:CHEBI:17368"
FT   Condition: [RK]
FT   BINDING         192
FT                   /ligand="hypoxanthine"
FT                   /ligand_id="ChEBI:CHEBI:17368"
FT   Optional; Condition: T
FT   BINDING         221
FT                   /ligand="hypoxanthine"
FT                   /ligand_id="ChEBI:CHEBI:17368"
FT   Condition: F
FT   BINDING         275
FT                   /ligand="hypoxanthine"
FT                   /ligand_id="ChEBI:CHEBI:17368"
FT   Condition: D
XX
Size: 333-341;
Related: None;
Template: P0ACP7;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.19 2022/11/19
//