AC   MF_01282;
DC   Protein; auto
TR   HAMAP; MF_01282; -; 1; level=0
XX
Names: VirginiamycinB_lyase
XX
ID   VGB
DE   RecName: Full=Virginiamycin B lyase;
DE            EC=4.2.99.-;
DE   AltName: Full=Streptogramin B lyase;
GN   Name=vgb;
XX
CC   -!- FUNCTION: Inactivates the type B streptogramin antibiotics by
CC       linearizing the lactone ring at the ester linkage, generating a free
CC       phenylglycine carboxylate and converting the threonyl moiety into 2-
CC       amino-butenoic acid.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- SUBUNIT: Monomer.
CC   -!- SIMILARITY: Belongs to the Vgb family.
XX
DR   Pfam; PF08450; SGL; 1; trigger=no
DR   Pfam; PF01436; NHL; 1; trigger=no
XX
KW   Antibiotic resistance
KW   Lyase
KW   Magnesium
KW   Metal-binding
XX
GO   GO:0016835; F:carbon-oxygen lyase activity
GO   GO:0017001; P:antibiotic catabolic process
XX
FT   From: VGB_STAAU (P17978)
FT   ACT_SITE        270
FT                   /note="Proton acceptor"
FT   Condition: H
FT   BINDING         268
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: E
FT   BINDING         284
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: E
FT   BINDING         228
FT                   /ligand="substrate"
FT   Condition: H
XX
Size: 279-300;
Related: None;
Template: P17978; Q7W0D3; Q9KZX7;
Scope:
 Bacteria; Actinomycetota
 Bacteria; Bacillota
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in STAAU
Comments: None
XX
# Revision 1.20 2023/01/26
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