AC   MF_01285;
DC   Protein; auto
TR   HAMAP; MF_01285; -; 1; level=0
XX
Names: Riboflavin_kinase
XX
ID   RIFK
DE   RecName: Full=Riboflavin kinase;
DE            Short=RFK;
DE            EC=2.7.1.161;
DE   AltName: Full=CTP-dependent riboflavin kinase;
DE   AltName: Full=CTP:riboflavin 5'-phosphotransferase;
DE   AltName: Full=Flavokinase;
GN   Name=ribK;
XX
CC   -!- FUNCTION: Catalyzes the CTP-dependent phosphorylation of riboflavin
CC       (vitamin B2) to form flavin mononucleotide (FMN).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CTP + riboflavin = CDP + FMN + H(+); Xref=Rhea:RHEA:25021,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:37563, ChEBI:CHEBI:57986,
CC         ChEBI:CHEBI:58069, ChEBI:CHEBI:58210; EC=2.7.1.161;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Note=Binds 1 Mg(2+) ion per subunit.;
CC   -!- PATHWAY: Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin
CC       (CTP route): step 1/1.
CC   -!- SIMILARITY: Belongs to the archaeal riboflavin kinase family.
XX
DR   Pfam; PF01982; CTP-dep_RFKase; 1; trigger=no
XX
KW   Flavoprotein
KW   FMN
KW   Kinase
KW   Magnesium
KW   Metal-binding
KW   Transferase
KW   Nucleotide-binding
XX
GO   GO:0000166; F:nucleotide binding
GO   GO:0000287; F:magnesium ion binding
GO   GO:0016301; F:kinase activity
GO   GO:0016773; F:phosphotransferase activity, alcohol group as acceptor
GO   GO:0009398; P:FMN biosynthetic process
XX
FT   From: RIFK_METJA (Q60365)
FT   BINDING         10..15
FT                   /ligand="CDP"
FT                   /ligand_id="ChEBI:CHEBI:58069"
FT   BINDING         108..111
FT                   /ligand="CDP"
FT                   /ligand_id="ChEBI:CHEBI:58069"
FT   BINDING         39
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: T
FT   BINDING         41
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: N
FT   BINDING         95
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT   Condition: [TS]
FT   BINDING         96
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT   Optional; Condition: Y
FT   BINDING         103
FT                   /ligand="FMN"
FT                   /ligand_id="ChEBI:CHEBI:58210"
FT   Condition: E
XX
Size: 122-159;
Related: None;
Template: Q60365;
Scope:
 Archaea
Fusion:
 Nter: <Unknown>
 Cter: None
Duplicate: None
Plasmid: None
Comments: Many family members are N-terminally fused with a putative winged HTH DNA-binding domain,
 that has not been annotated because of bad score and truncation.
 Possible wrong start in SULAC.
 Longer N-terminus in SACS2 and IGNH4.
XX
# Revision 1.20 2022/11/19
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