AC   MF_01290;
DC   Protein; auto
TR   HAMAP; MF_01290; -; 1; level=0
XX
Names: KDR_aldolase
XX
ID   RHMA
DE   RecName: Full=2-keto-3-deoxy-L-rhamnonate aldolase;
DE            Short=KDR aldolase;
DE            EC=4.1.2.53;
DE   AltName: Full=2-dehydro-3-deoxyrhamnonate aldolase;
GN   Name=rhmA;
XX
CC   -!- FUNCTION: Catalyzes the reversible retro-aldol cleavage of 2-keto-3-
CC       deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-dehydro-3-deoxy-L-rhamnonate = (S)-lactaldehyde + pyruvate;
CC         Xref=Rhea:RHEA:25784, ChEBI:CHEBI:15361, ChEBI:CHEBI:18041,
CC         ChEBI:CHEBI:58371; EC=4.1.2.53;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Note=Binds 1 Mg(2+) ion per subunit.;
end case
CC   -!- SUBUNIT: Homohexamer.
CC   -!- SIMILARITY: Belongs to the HpcH/HpaI aldolase family. KDR aldolase
CC       subfamily.
XX
DR   Pfam; PF03328; HpcH_HpaI; 1; trigger=no
XX
KW   Lyase
case <FTGroup:1>
KW   Magnesium
KW   Metal-binding
end case
XX
case <FTGroup:1>
GO   GO:0000287; F:magnesium ion binding
end case
GO   GO:0016832; F:aldehyde-lyase activity
XX
FT   From: RHMA_ECOLI (P76469)
FT   ACT_SITE        49
FT                   /note="Proton acceptor"
FT   Condition: H
FT   BINDING         153
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Group: 1; Condition: E
FT   BINDING         179
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Group: 1; Condition: D
FT   BINDING         151
FT                   /ligand="substrate"
FT   Condition: Q
FT   BINDING         178
FT                   /ligand="substrate"
FT   Condition: A
FT   BINDING         179
FT                   /ligand="substrate"
FT   Condition: D
FT   SITE            74
FT                   /note="Transition state stabilizer"
FT   Condition: R
FT   SITE            88
FT                   /note="Increases basicity of active site His"
FT   Condition: D
XX
Size: 267-267;
Related: None;
Template: P76469;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.14 2022/11/19
//