AC   MF_01293;
DC   Protein; auto
TR   HAMAP; MF_01293; -; 1; level=0
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Names: TagBP_aldolase_KbaY
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ID   KBAY
DE   RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit KbaY;
DE            Short=TBPA;
DE            Short=TagBP aldolase;
DE            EC=4.1.2.40;
DE   AltName: Full=D-tagatose-bisphosphate aldolase class II;
DE   AltName: Full=Ketose 1,6-bisphosphate aldolase class II;
DE   AltName: Full=Tagatose-bisphosphate aldolase;
GN   Name=kbaY;
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CC   -!- FUNCTION: Catalytic subunit of the tagatose-1,6-bisphosphate aldolase
CC       KbaYZ, which catalyzes the reversible aldol condensation of
CC       dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with
CC       glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate
CC       (TBP). Requires KbaZ subunit for full activity and stability.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2.
CC   -!- SUBUNIT: Homotetramer. Forms a complex with KbaZ.
CC   -!- SIMILARITY: Belongs to the class II fructose-bisphosphate aldolase
CC       family. TagBP aldolase KbaY subfamily.
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DR   PROSITE; PS00602; ALDOLASE_CLASS_II_1; 1; trigger=no
DR   PROSITE; PS00806; ALDOLASE_CLASS_II_2; 1; trigger=no
DR   Pfam; PF01116; F_bP_aldolase; 1; trigger=no
DR   NCBIfam; TIGR00167; CbbA; 1; trigger=no
DR   NCBIfam; TIGR01858; Tag_bisphos_ald; 1; trigger=no
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KW   Lyase
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
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case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
GO   GO:0009025; F:tagatose-bisphosphate aldolase activity
GO   GO:0005975; P:carbohydrate metabolic process
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FT   From: KBAY_ECOLI (P0AB74)
FT   BINDING         230..233
FT                   /ligand="dihydroxyacetone phosphate"
FT                   /ligand_id="ChEBI:CHEBI:57642"
FT   Condition: N-x-A-T
FT   BINDING         209..211
FT                   /ligand="dihydroxyacetone phosphate"
FT                   /ligand_id="ChEBI:CHEBI:57642"
FT   Condition: G-x-S
FT   ACT_SITE        82
FT                   /note="Proton donor"
FT   Condition: D
FT   BINDING         83
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         180
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         208
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         181
FT                   /ligand="dihydroxyacetone phosphate"
FT                   /ligand_id="ChEBI:CHEBI:57642"
FT   Condition: G
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Size: 286-292;
Related: MF_01294;
Template: P0AB74; Q9KIP8;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Subunit kbaZ is described in MF_01295.
 In some enterobacteria, a second D-tagatose-1,6-bisphosphate aldolase is
 present: gatYZ (MF_01294 and MF_01296).
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# Revision 1.14 2023/06/01
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