AC   MF_01294;
DC   Protein; auto
TR   HAMAP; MF_01294; -; 1; level=0
XX
Names: TagBP_aldolase_GatY
XX
ID   GATY
DE   RecName: Full=D-tagatose-1,6-bisphosphate aldolase subunit GatY;
DE            Short=TBPA;
DE            Short=TagBP aldolase;
DE            EC=4.1.2.40;
DE   AltName: Full=D-tagatose-bisphosphate aldolase class II;
DE   AltName: Full=Tagatose-bisphosphate aldolase;
GN   Name=gatY;
XX
CC   -!- FUNCTION: Catalytic subunit of the tagatose-1,6-bisphosphate aldolase
CC       GatYZ, which catalyzes the reversible aldol condensation of
CC       dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with
CC       glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate
CC       (TBP). Requires GatZ subunit for full activity and stability. Is
CC       involved in the catabolism of galactitol.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-tagatofuranose 1,6-bisphosphate = D-glyceraldehyde 3-
CC         phosphate + dihydroxyacetone phosphate; Xref=Rhea:RHEA:22948,
CC         ChEBI:CHEBI:57642, ChEBI:CHEBI:58694, ChEBI:CHEBI:59776; EC=4.1.2.40;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- PATHWAY: Carbohydrate metabolism; D-tagatose 6-phosphate degradation;
CC       D-glyceraldehyde 3-phosphate and glycerone phosphate from D-tagatose 6-
CC       phosphate: step 2/2.
CC   -!- SUBUNIT: Forms a complex with GatZ.
CC   -!- SIMILARITY: Belongs to the class II fructose-bisphosphate aldolase
CC       family. TagBP aldolase GatY subfamily.
XX
DR   PROSITE; PS00602; ALDOLASE_CLASS_II_1; 1; trigger=no
DR   PROSITE; PS00806; ALDOLASE_CLASS_II_2; 1; trigger=no
DR   Pfam; PF01116; F_bP_aldolase; 1; trigger=no
DR   NCBIfam; TIGR00167; CbbA; 1; trigger=no
DR   NCBIfam; TIGR01858; Tag_bisphos_ald; 1; trigger=no
XX
KW   Galactitol metabolism
KW   Lyase
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
GO   GO:0009025; F:tagatose-bisphosphate aldolase activity
GO   GO:0019404; P:galactitol catabolic process
XX
FT   From: GATY_ECOLI (P0C8J6)
FT   BINDING         230..233
FT                   /ligand="dihydroxyacetone phosphate"
FT                   /ligand_id="ChEBI:CHEBI:57642"
FT   Condition: N-x-A-T
FT   BINDING         209..211
FT                   /ligand="dihydroxyacetone phosphate"
FT                   /ligand_id="ChEBI:CHEBI:57642"
FT   Condition: G-x-S
FT   ACT_SITE        82
FT                   /note="Proton donor"
FT   Condition: D
FT   BINDING         83
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         180
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         208
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         181
FT                   /ligand="dihydroxyacetone phosphate"
FT                   /ligand_id="ChEBI:CHEBI:57642"
FT   Condition: [GC]
XX
Size: 284-284;
Related: MF_01293;
Template: P0C8J6; P0C8J7; Q8VS16;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Subunit gatZ is described in MF_01296.
 In some enterobacteria, a second D-tagatose-1,6-bisphosphate aldolase is
 present: kbaYZ (MF_01293 and MF_01295).
XX
# Revision 1.15 2023/06/01
//