AC MF_01359; DC Protein; auto TR HAMAP; MF_01359; -; 1; level=0 XX Names: NDH1_NuoCD_1 XX ID NUOCD DE RecName: Full=NADH-quinone oxidoreductase subunit C/D; DE EC=7.1.1.-; DE AltName: Full=NADH dehydrogenase I subunit C/D; DE AltName: Full=NDH-1 subunit C/D; GN Name=nuoC; Synonyms=nuoCD, nuoD; XX CC -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur CC (Fe-S) centers, to quinones in the respiratory chain. The immediate CC electron acceptor for the enzyme in this species is believed to be CC ubiquinone. Couples the redox reaction to proton translocation (for CC every two electrons transferred, four hydrogen ions are translocated CC across the cytoplasmic membrane), and thus conserves the redox energy CC in a proton gradient. CC -!- CATALYTIC ACTIVITY: CC Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; CC -!- SUBUNIT: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, CC E, F, and G constitute the peripheral sector of the complex. case not defined or CC -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; CC Cytoplasmic side. else case CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; CC Cytoplasmic side. end case CC -!- SIMILARITY: In the N-terminal section; belongs to the complex I 30 kDa CC subunit family. CC -!- SIMILARITY: In the C-terminal section; belongs to the complex I 49 kDa CC subunit family. XX DR PROSITE; PS00542; COMPLEX1_30K; 1; trigger=no DR PROSITE; PS00535; COMPLEX1_49K; 1; trigger=no DR Pfam; PF00329; Complex1_30kDa; 1; trigger=no DR Pfam; PF00346; Complex1_49kDa; 1; trigger=no DR NCBIfam; TIGR01961; NuoC_fam; 1; trigger=no DR NCBIfam; TIGR01962; NuoD; 1; trigger=no XX case defined and KW Cell inner membrane end case KW Cell membrane KW Membrane KW Multifunctional enzyme KW NAD KW Quinone KW Ubiquinone KW Translocase KW Transport XX GO GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO GO:0050136; F:NADH dehydrogenase (quinone) activity GO GO:0005886; C:plasma membrane XX FT From: NUOCD_ECOLI (P33599) FT REGION Nter..186 FT /note="NADH dehydrogenase I subunit C" FT REGION 210..Cter FT /note="NADH dehydrogenase I subunit D" XX Size: 578-608; Related: MF_01357; MF_01358; MF_01397; Template: P33599; Scope: Bacteria; Alphaproteobacteria Bacteria; Betaproteobacteria Bacteria; Gammaproteobacteria Fusion: Nter: MF_01356 (nuoB) Cter: None Duplicate: None Plasmid: None Comments: This family is specific for the nuoC-nuoD fusion found in the Alpha-, Beta-, Gamma- and some Deltaproteobacteria. The nuoCD fusion protein found in the Aquificae, Bacteroidetes, some other Delta- and Epsilonproteobacteria is different enough that it seems to be another subfamily (MF_01397). The Geobacter, SYNC1 and SYNFM nuoBCD fusion proteins are also members of this family. The individual families are MF_01357 (nuoC) and MF_01358 (nuoD). In many bacteria there are both the individual and fused versions. 14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature. XX # Revision 1.18 2023/06/01 //