AC   MF_01364;
DC   Protein; auto
c?   <OC:Bacteria> or <OG:Chloroplast>
TR   HAMAP; MF_01364_B; -; 1; level=0
c?   <OC:Archaea>
TR   HAMAP; MF_01364_A; -; 1; level=0
XX
Names: Ribosomal_uS14_2
XX
case <OC:Bacteria> and not <OC:Cyanobacteriota>
ID   RS14Z
DE   RecName: Full=Small ribosomal subunit protein uS14;
GN   Name=rpsZ; Synonyms=rpsN;
else case <OC:Cyanobacteriota>
ID   RS14Z
DE   RecName: Full=Small ribosomal subunit protein uS14;
GN   Name=rpsZ; Synonyms=rps14, rpsN;
else case <OC:Archaea>
ID   RS14Z
DE   RecName: Full=Small ribosomal subunit protein uS14;
GN   Name=rps14;
end case
XX
case <OC:Bacteria>
CC   -!- FUNCTION: Binds 16S rRNA, required for the assembly of 30S particles
CC       and may also be responsible for determining the conformation of the 16S
CC       rRNA at the A site.
CC   -!- SUBUNIT: Part of the 30S ribosomal subunit. Contacts proteins S3 and
CC       S10.
else
CC   -!- FUNCTION: Binds 16S rRNA, required for the assembly of 30S particles.
CC   -!- SUBUNIT: Part of the 30S ribosomal subunit.
end case
case <FTGroup:1> or <FTGroup:2>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uS14 family.
CC       Zinc-binding uS14 subfamily.
XX
DR   PROSITE; PS00527; RIBOSOMAL_S14; 1; trigger=no
DR   Pfam; PF00253; Ribosomal_S14; 1; trigger=no
XX
KW   Ribonucleoprotein
KW   Ribosomal protein
KW   RNA-binding
KW   rRNA-binding
case <FTGroup:1> or <FTGroup:2>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0006412; P:translation
GO   GO:0019843; F:rRNA binding
case <FTGroup:1> or <FTGroup:2>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: RS14Z_THET8 (P0DOY6)
case <OC:Bacteria>
FT   BINDING         24
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 1; Condition: C
FT   BINDING         27
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 1; Condition: C
FT   BINDING         40
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 1; Condition: C
FT   BINDING         43
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 1; Condition: C
end case
FT   From: RS14Z_HALMA (P26816)
case <OC:Archaea>
FT   BINDING         26
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 2; Condition: C
FT   BINDING         29
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 2; Condition: C
FT   BINDING         44
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 2; Condition: C
FT   BINDING         47
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Optional; Group: 2; Condition: C
end case
XX
case <OC:Bacteria>
Size: 60-62;
end case
case <OC:Archaea>
Size: 47-69;
end case
Related: MF_00537!;
Template: P0DOY6;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACLD, NATMM, NATPD
Plasmid: in NATMM
Comments: In bacteria this gene has been subject to horizontal gene transfer,
 subsequent differential gene loss and insertions/deletions near the N-terminus.
 The ancestral version is most likely the shortest one (group I of PubMed
 11102698) which has conserved cysteine residues that in the case of Thermus
 thermophilus have been shown to bind zinc. We have chosen to use the identifier
 RS14Z in bacteria for the zinc-binding subfamily (this family, MF_01364). The
 group II proteins have an approximately 23 amino acid insertion and the group
 III proteins have an approximately 38 residue insertion; we do not distinguish
 between them however (MF_00537); members of this subfamily do not usually
 possess the conserved cysteine residues. Many bacteria possess more than one
 copy of RS14, usually one of which is able to bind zinc. Interestingly, in the
 proteobacteria (Pseudomonadota, which usually have the group III form) the
 acquired form is found within the spc operon, signifying gene replacement took
 place within the operon.
 See:
 PubMed=11102698;
 Brochier C., Philippe H., Moreira D.;
 "The evolutionary history of ribosomal protein RpS14: horizontal gene
 transfer at the heart of the ribosome.";
 Trends Genet. 16:529-533(2000).
 PubMed=11574053;
 Makarova K.S., Ponomarev V.A., Koonin E.V.;
 "Two C or not two C: recurrent disruption of Zn-ribbons, gene
 duplication, lineage-specific gene loss, and horizontal gene transfer
 in evolution of bacterial ribosomal proteins.";
 Genome Biol. 2:RESEARCH 0033-RESEARCH 0033(2001).
XX
# Revision 1.28 2023/09/22
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