AC MF_01384; DC Protein; auto TR HAMAP; MF_01384; -; 1; level=0 XX Names: UreD XX case not ID URED DE RecName: Full=Urease accessory protein UreD; GN Name=ureD; else case ID UREH DE RecName: Full=Urease accessory protein UreH; GN Name=ureH; end case XX CC -!- FUNCTION: Required for maturation of urease via the functional CC incorporation of the urease nickel metallocenter. case not CC -!- SUBUNIT: UreD, UreF and UreG form a complex that acts as a GTP- CC hydrolysis-dependent molecular chaperone, activating the urease CC apoprotein by helping to assemble the nickel containing metallocenter CC of UreC. The UreE protein probably delivers the nickel. else case CC -!- SUBUNIT: UreH, UreF and UreG form a complex that acts as a GTP- CC hydrolysis-dependent molecular chaperone, activating the urease CC apoprotein by helping to assemble the nickel containing metallocenter CC of UreC. The UreE protein probably delivers the nickel. end case CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the UreD family. XX DR Pfam; PF01774; UreD; 1; trigger=no XX KW Chaperone KW Cytoplasm KW Nickel insertion XX GO GO:0016151; F:nickel cation binding GO GO:0005737; C:cytoplasm XX Size: 240-329; Related: None; Template: Q09063; P17089; Q9ZFR5; Scope: Bacteria; Actinomycetota Bacteria; Bacteroidota Bacteria; Chloroflexota Bacteria; Cyanobacteriota Bacteria; Deinococcota Bacteria; Bacillota Bacteria; Magnetococcus Bacteria; Pseudomonadota Bacteria; Mycoplasmatota Bacteria; Verrucomicrobiota Archaea Fusion: Nter: None Cter: None Duplicate: in BRASB, BRASO, BRUAB, BRUA2, BRUC2, BRUME, BRUO2, BRUSU, METEP, METPB, METRJ, BRUA4, PSESM, PSEU2, PSYCK, SACEN, STRGG, SYNJA Plasmid: in ECOLX, HALMA, METRJ Comments: Called ureH in Helicobacter where ureD is an unrelated protein of the urease operon. Some E.coli EHEC strains are urease negative despite the presence of the operon in their genomes; in a few cases this has been shown to be due to nonsense mutations in ureD, for example ECO57. YERPE has a different nonsense mutation and is also non-functional. For some orally acquired pathogens (Brucella, Helicobacter, YERPE) urease acts as a virulence factor. In Brucella there are usually 2 urease operons. XX # Revision 1.17 2023/02/17 //