AC MF_01397; DC Protein; auto TR HAMAP; MF_01397; -; 1; level=0 XX Names: NDH1_NuoCD_2 XX ID NUOCD DE RecName: Full=NADH-quinone oxidoreductase subunit C/D; DE EC=7.1.1.-; DE AltName: Full=NADH dehydrogenase I subunit C/D; DE AltName: Full=NDH-1 subunit C/D; DE AltName: Full=NUO3/NUO4; GN Name=nuoC; XX CC -!- FUNCTION: NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur CC (Fe-S) centers, to quinones in the respiratory chain. The immediate CC electron acceptor for the enzyme in this species is believed to be CC ubiquinone. Couples the redox reaction to proton translocation (for CC every two electrons transferred, four hydrogen ions are translocated CC across the cytoplasmic membrane), and thus conserves the redox energy CC in a proton gradient. CC -!- CATALYTIC ACTIVITY: CC Reaction=a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:57888, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; CC -!- SUBUNIT: NDH-1 is composed of 13 different subunits. Subunits NuoB, CD, CC E, F, and G constitute the peripheral sector of the complex. CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein. CC -!- SIMILARITY: In the N-terminal section; belongs to the complex I 30 kDa CC subunit family. CC -!- SIMILARITY: In the C-terminal section; belongs to the complex I 49 kDa CC subunit family. XX DR PROSITE; PS00542; COMPLEX1_30K; 1; trigger=no DR PROSITE; PS00535; COMPLEX1_49K; 1; trigger=no DR Pfam; PF00329; Complex1_30kDa; 1; trigger=no DR Pfam; PF00346; Complex1_49kDa; 1; trigger=no DR NCBIfam; TIGR01961; NuoC_fam; 1; trigger=no DR NCBIfam; TIGR01962; NuoD; 1; trigger=no XX KW Cell inner membrane KW Cell membrane KW Cytoplasm KW Membrane KW Multifunctional enzyme KW NAD KW Quinone KW Translocase KW Transport KW Ubiquinone XX GO GO:0016655; F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO GO:0050136; F:NADH dehydrogenase (quinone) activity GO GO:0005886; C:plasma membrane XX FT From: NUOCD_BDEBA (Q6MIR5) FT REGION Nter..157 FT /note="NADH dehydrogenase I subunit C" FT REGION 175..Cter FT /note="NADH dehydrogenase I subunit D" XX Size: 519-593; Related: MF_01357; MF_01358; MF_01359; Template: P33599; Scope: Bacteria; Aquificae Bacteria; Bacteroidia Bacteria; Deltaproteobacteria Bacteria; Campylobacteraceae Fusion: Nter: None Cter: None Duplicate: in AQUAE Plasmid: None Comments: This family is specific for the nuoC-nuoD fusion found in Aquificae, Bacteroidetes, Delta-and Epsilonproteobacteria. The nuoCD fusion protein found in the Alpha-, Beta- and Gammaproteobacteria is different enough that it seems to be another subfamily (MF_01359). The individual families are MF_01357 (nuoC) and MF_01358 (nuoD). In many bacteria there are both the individual and fused versions. 14 proteins form the NDH-1 complex in most bacteria, there are at least 15 subunits in cyanobacteria and chloroplasts. PARDE and THET8 are annotated with another nomenclature. XX # Revision 1.12 2023/06/01 //