AC   MF_01401;
DC   Protein; auto
TR   HAMAP; MF_01401; -; 1; level=0
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Names: MsrA
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ID   MSRA
DE   RecName: Full=Peptide methionine sulfoxide reductase MsrA;
DE            Short=Protein-methionine-S-oxide reductase;
DE            EC=1.8.4.11;
DE   AltName: Full=Peptide-methionine (S)-S-oxide reductase;
DE            Short=Peptide Met(O) reductase;
GN   Name=msrA;
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CC   -!- FUNCTION: Has an important function as a repair enzyme for proteins
CC       that have been inactivated by oxidation. Catalyzes the reversible
CC       oxidation-reduction of methionine sulfoxide in proteins to methionine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[thioredoxin]-disulfide + H2O + L-methionyl-[protein] =
CC         [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein];
CC         Xref=Rhea:RHEA:14217, Rhea:RHEA-COMP:10698, Rhea:RHEA-COMP:10700,
CC         Rhea:RHEA-COMP:12313, Rhea:RHEA-COMP:12315, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:16044, ChEBI:CHEBI:29950, ChEBI:CHEBI:44120,
CC         ChEBI:CHEBI:50058; EC=1.8.4.11;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-
CC         dithiol + L-methionine (S)-S-oxide; Xref=Rhea:RHEA:19993, Rhea:RHEA-
CC         COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57844,
CC         ChEBI:CHEBI:58772; EC=1.8.4.11;
CC   -!- SIMILARITY: Belongs to the MsrA Met sulfoxide reductase family.
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DR   Pfam; PF01625; PMSR; 1; trigger=no
DR   NCBIfam; TIGR00401; MsrA; 1; trigger=no
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KW   Oxidoreductase
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GO   GO:0008113; F:peptide-methionine (S)-S-oxide reductase activity
GO   GO:0036211; P:protein modification process
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FT   From: MSRA_ECOLI (P0A744)
FT   ACT_SITE        52
FT   Condition: C
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Size: 123-222;
Related: None;
Template: P14930; Q9JWM8;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: MF_01400 (msrB); <Thioredoxin domain>
 Cter: MF_01400 (msrB)
Duplicate: in NOSS1, CAUVC, LACLA, RHILO, RHIME, RHOBA, STAAU, SYNY3
Plasmid: in RHIME
Comments: None
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# Revision 1.30 2023/06/01
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