AC   MF_01405;
DC   Protein; auto
TR   HAMAP; MF_01405; -; 1; level=0
XX
Names: Non_canon_purine_NTPase
XX
ID   IXTPA
DE   RecName: Full=dITP/XTP pyrophosphatase;
DE            EC=3.6.1.66;
DE   AltName: Full=Non-canonical purine NTP pyrophosphatase;
DE   AltName: Full=Non-standard purine NTP pyrophosphatase;
DE   AltName: Full=Nucleoside-triphosphate diphosphatase;
DE   AltName: Full=Nucleoside-triphosphate pyrophosphatase;
DE            Short=NTPase;
XX
CC   -!- FUNCTION: Pyrophosphatase that catalyzes the hydrolysis of nucleoside
CC       triphosphates to their monophosphate derivatives, with a high
CC       preference for the non-canonical purine nucleotides XTP (xanthosine
CC       triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to
CC       function as a house-cleaning enzyme that removes non-canonical purine
CC       nucleotides from the nucleotide pool, thus preventing their
CC       incorporation into DNA/RNA and avoiding chromosomal lesions.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + XTP = diphosphate + H(+) + XMP; Xref=Rhea:RHEA:28610,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57464, ChEBI:CHEBI:61314; EC=3.6.1.66;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dITP + H2O = dIMP + diphosphate + H(+); Xref=Rhea:RHEA:28342,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61194, ChEBI:CHEBI:61382; EC=3.6.1.66;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + ITP = diphosphate + H(+) + IMP; Xref=Rhea:RHEA:29399,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:58053, ChEBI:CHEBI:61402; EC=3.6.1.66;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Note=Binds 1 Mg(2+) ion per subunit.;
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the HAM1 NTPase family.
XX
DR   Pfam; PF01725; Ham1p_like; 1; trigger=no
DR   NCBIfam; TIGR00042; TIGR00042; 1; trigger=no
XX
KW   Hydrolase
KW   Magnesium
KW   Metal-binding
KW   Nucleotide metabolism
KW   Nucleotide-binding
XX
GO   GO:0047429; F:nucleoside triphosphate diphosphatase activity
GO   GO:0009146; P:purine nucleoside triphosphate catabolic process
XX
FT   From: IXTPA_PYRHO (O59580)
FT   BINDING         7..12
FT                   /ligand="substrate"
FT   Condition: [TS]-x-[NSH]-x-x-K
FT   BINDING         140..143
FT                   /ligand="substrate"
FT   Condition: [FWH]-x-x-[DN]
FT   BINDING         168..169
FT                   /ligand="substrate"
FT   Condition: H-R
FT   ACT_SITE        65
FT                   /note="Proton acceptor"
FT   Condition: D
FT   BINDING         36
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Optional; Condition: [ED]
FT   BINDING         65
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Condition: D
FT   BINDING         66
FT                   /ligand="substrate"
FT   Condition: [STA]
FT   BINDING         163
FT                   /ligand="substrate"
FT   Condition: K
XX
Size: 178-328;
Related: None;
Template: P52061; Q57679; O59580; O28046;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: MF_00564 (rph); <Unknown>
 Cter: None
Duplicate: None
Plasmid: None
Comments: Unknown N-terminal domain in STRA3, STRA5, STRP1, STRP6, STRP8, STRT1,
 STRT2
XX
# Revision 1.31 2023/06/01
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