AC MF_01414; DC Protein; auto TR HAMAP; MF_01414; -; 1; level=0 XX Names: K_H_efflux_KefF XX ID KEFF DE RecName: Full=Glutathione-regulated potassium-efflux system ancillary protein KefF; DE AltName: Full=Quinone oxidoreductase KefF; DE EC=1.6.5.2; GN Name=kefF; XX CC -!- FUNCTION: Regulatory subunit of a potassium efflux system that confers CC protection against electrophiles. Required for full activity of KefC. CC Shows redox enzymatic activity, but this enzymatic activity is not CC required for activation of KefC. CC -!- CATALYTIC ACTIVITY: CC Reaction=a quinone + H(+) + NADH = a quinol + NAD(+); CC Xref=Rhea:RHEA:46160, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:132124; EC=1.6.5.2; CC -!- CATALYTIC ACTIVITY: CC Reaction=a quinone + H(+) + NADPH = a quinol + NADP(+); CC Xref=Rhea:RHEA:46164, ChEBI:CHEBI:15378, ChEBI:CHEBI:24646, CC ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:132124; EC=1.6.5.2; CC -!- COFACTOR: CC Name=FMN; Xref=ChEBI:CHEBI:58210; CC -!- SUBUNIT: Homodimer. Interacts with KefC. CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein; CC Cytoplasmic side. CC -!- SIMILARITY: Belongs to the NAD(P)H dehydrogenase (quinone) family. KefF CC subfamily. XX DR Pfam; PF02525; Flavodoxin_2; 1; trigger=no XX KW Cell inner membrane KW Cell membrane KW Flavoprotein KW FMN KW Membrane KW NAD KW Oxidoreductase XX GO GO:0003955; F:NAD(P)H dehydrogenase (quinone) activity GO GO:0010181; F:FMN binding GO GO:0032414; P:positive regulation of ion transmembrane transporter activity GO GO:1901381; P:positive regulation of potassium ion transmembrane transport XX FT From: KEFF_ECOLI (P0A754) FT BINDING 14..17 FT /ligand="FMN" FT /ligand_id="ChEBI:CHEBI:58210" FT Optional; Condition: S-x-x-N FT BINDING 65..68 FT /ligand="FMN" FT /ligand_id="ChEBI:CHEBI:58210" FT Optional; Condition: [ML]-x-W-Y FT BINDING 105..108 FT /ligand="FMN" FT /ligand_id="ChEBI:CHEBI:58210" FT Optional; Condition: T-x-G-x FT BINDING 8 FT /ligand="FMN" FT /ligand_id="ChEBI:CHEBI:58210" FT Optional; Condition: H XX Size: 160-200; Related: None; Template: P0A754; Scope: Bacteria; Gammaproteobacteria Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: KefF is the ancillary protein of KefC, whereas KefG is the ancillary protein of KefB. KefF and KefG cannot complement each other and are specific for their respective efflux system XX # Revision 1.16 2022/11/19 //