AC   MF_01417;
DC   Protein; auto
TR   HAMAP; MF_01417; -; 1; level=0
XX
Names: SpeA
XX
ID   SPEA
DE   RecName: Full=Biosynthetic arginine decarboxylase;
DE            Short=ADC;
DE            EC=4.1.1.19;
GN   Name=speA;
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CC   -!- FUNCTION: Catalyzes the biosynthesis of agmatine from arginine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + L-arginine = agmatine + CO2; Xref=Rhea:RHEA:17641,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:58145; EC=4.1.1.19;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC   -!- PATHWAY: Amine and polyamine biosynthesis; agmatine biosynthesis;
CC       agmatine from L-arginine: step 1/1.
CC   -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
CC       SpeA subfamily.
XX
DR   Pfam; PF02784; Orn_Arg_deC_N; 1; trigger=no
DR   Pfam; PF00278; Orn_DAP_Arg_deC; 1; trigger=no
DR   PRINTS; PR01179; ODADCRBXLASE; 1; trigger=no
DR   NCBIfam; TIGR01273; SpeA; 1; trigger=no
DR   PROSITE; PS00878; ODR_DC_2_1; 1; trigger=no
DR   PROSITE; PS00879; ODR_DC_2_2; 1; trigger=no
XX
KW   Polyamine biosynthesis
KW   Spermidine biosynthesis
case <OC:Enterobacterales> or <OC:Neisseriales>
KW   Putrescine biosynthesis
end case
KW   Lyase
KW   Decarboxylase
KW   Pyridoxal phosphate
KW   Metal-binding
KW   Magnesium
XX
GO   GO:0008792; F:arginine decarboxylase activity
case <OC:Enterobacterales> or <OC:Neisseriales>
GO   GO:0009446; P:putrescine biosynthetic process
end case
GO   GO:0008295; P:spermidine biosynthetic process
XX
FT   From: SPEA_ECOLI (P21170)
FT   BINDING         307..317
FT                   /ligand="substrate"
FT   Condition: [FIVLC]-[DN]-[IV]-G-G-G-L-[GA]-[VI]-D-[YF]
FT   MOD_RES         127
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT   Condition: K
XX
Size: 626-695;
Related: None;
Template: P21170;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in SYNY3
Plasmid: None
Comments: None
XX
# Revision 1.28 2023/06/01
//