AC   MF_01418;
DC   Protein; auto
TR   HAMAP; MF_01418; -; 1; level=0
XX
Names: SpeB
XX
ID   SPEB
DE   RecName: Full=Agmatinase;
DE            EC=3.5.3.11;
DE   AltName: Full=Agmatine ureohydrolase;
DE            Short=AUH;
GN   Name=speB;
XX
CC   -!- FUNCTION: Catalyzes the formation of putrescine from agmatine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=agmatine + H2O = putrescine + urea; Xref=Rhea:RHEA:13929,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:16199, ChEBI:CHEBI:58145,
CC         ChEBI:CHEBI:326268; EC=3.5.3.11;
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC   -!- PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis via
CC       agmatine pathway; putrescine from agmatine: step 1/1.
CC   -!- SIMILARITY: Belongs to the arginase family. Agmatinase subfamily.
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DR   Pfam; PF00491; Arginase; 1; trigger=no
DR   NCBIfam; TIGR01230; Agmatinase; 1; trigger=no
DR   PROSITE; PS01053; ARGINASE_1; 1; trigger=no
DR   PROSITE; PS51409; ARGINASE_2; 1; trigger=no
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KW   Polyamine biosynthesis
KW   Spermidine biosynthesis
KW   Putrescine biosynthesis
KW   Hydrolase
KW   Metal-binding
KW   Manganese
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GO   GO:0008783; F:agmatinase activity
GO   GO:0009446; P:putrescine biosynthetic process
GO   GO:0008295; P:spermidine biosynthetic process
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FT   From: SPEB_ECOLI (P60651)
FT   BINDING         126
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT   Condition: H
FT   BINDING         149
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT   Condition: D
FT   BINDING         151
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT   Condition: H
FT   BINDING         153
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT   Condition: D
FT   BINDING         230
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT   Condition: D
FT   BINDING         232
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT   Condition: D
XX
Size: 303-322;
Related: None;
Template: P60651;
Scope:
 Bacteria; Neisseriales
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: This protein has not been found in Yersinia pestis.
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# Revision 1.23 2023/06/01
//