AC   MF_01425;
DC   Protein; auto
TR   HAMAP; MF_01425; -; 1; level=0
XX
Names: Cation_efflux_FieF
XX
ID   FIEF
DE   RecName: Full=Cation-efflux pump FieF;
GN   Name=fieF;
XX
CC   -!- FUNCTION: Divalent metal cation transporter which exports Zn(2+),
CC       Cd(2+) and possibly Fe(2+). May be involved in zinc and iron
CC       detoxification by efflux.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(out) + Zn(2+)(in) = H(+)(in) + Zn(2+)(out);
CC         Xref=Rhea:RHEA:28839, ChEBI:CHEBI:15378, ChEBI:CHEBI:29105;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cd(2+)(in) + H(+)(out) = Cd(2+)(out) + H(+)(in);
CC         Xref=Rhea:RHEA:28739, ChEBI:CHEBI:15378, ChEBI:CHEBI:48775;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in);
CC         Xref=Rhea:RHEA:29439, ChEBI:CHEBI:15378, ChEBI:CHEBI:29033;
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC       transporter (TC 2.A.4) family. FieF subfamily.
XX
DR   Pfam; PF01545; Cation_efflux; 1; trigger=no
DR   NCBIfam; TIGR01297; CDF; 1; trigger=no
DR   General; Transmembrane; -; 5-6; trigger=yes
XX
KW   Cell inner membrane
KW   Cell membrane
KW   Ion transport
KW   Iron
KW   Iron transport
KW   Membrane
KW   Metal-binding
KW   Transmembrane
KW   Transmembrane helix
KW   Zinc
KW   Zinc transport
XX
GO   GO:0015297; F:antiporter activity
GO   GO:0015086; F:cadmium ion transmembrane transporter activity
GO   GO:0005381; F:iron ion transmembrane transporter activity
GO   GO:0005385; F:zinc ion transmembrane transporter activity
GO   GO:0070574; P:cadmium ion transmembrane transport
GO   GO:0034755; P:iron ion transmembrane transport
GO   GO:0071577; P:zinc ion transmembrane transport
GO   GO:0005886; C:plasma membrane
XX
FT   From: FIEF_ECOLI (P69380)
FT   BINDING         45
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: D
FT   BINDING         49
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: D
FT   BINDING         153
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: H
FT   BINDING         157
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Condition: D
XX
Size: 280-320;
Related: None;
Template: P69380;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.27 2023/06/01
//