AC MF_01429; DC Protein; auto TR HAMAP; MF_01429; -; 1; level=0 XX Names: Fe_S_insert_IscA XX ID ISCA DE RecName: Full=Iron-binding protein IscA; DE AltName: Full=Iron-sulfur cluster assembly protein; GN Name=iscA; XX CC -!- FUNCTION: Is able to transfer iron-sulfur clusters to apo-ferredoxin. CC Multiple cycles of [2Fe2S] cluster formation and transfer are observed, CC suggesting that IscA acts catalytically. Recruits intracellular free CC iron so as to provide iron for the assembly of transient iron-sulfur CC cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin CC reductase system TrxA/TrxB. case CC -!- COFACTOR: CC Name=Fe cation; Xref=ChEBI:CHEBI:24875; CC Note=Binds 2 iron ions per dimer. The dimer may bind additional iron CC ions.; end case CC -!- SUBUNIT: Homodimer; may form tetramers and higher multimers. CC -!- SIMILARITY: Belongs to the HesB/IscA family. XX DR Pfam; PF01521; Fe-S_biosyn; 1; trigger=no DR NCBIfam; TIGR00049; TIGR00049; 1; trigger=no DR NCBIfam; TIGR02011; IscA; 1; trigger=no DR PROSITE; PS01152; HESB; 1; trigger=no XX KW Iron case KW Metal-binding end case XX GO GO:0005506; F:iron ion binding case GO GO:0016226; P:iron-sulfur cluster assembly end case XX FT From: ISCA_ECOLI (P0AAC8) FT BINDING 35 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT Group: 1; Condition: C FT BINDING 99 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT Group: 1; Condition: C FT BINDING 101 FT /ligand="Fe cation" FT /ligand_id="ChEBI:CHEBI:24875" FT Group: 1; Condition: C XX Size: 107-107; Related: None; Template: P0AAC8; Scope: Bacteria; Enterobacterales Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.19 2023/06/01 //