AC MF_01437; DC Protein; auto TR HAMAP; MF_01437; -; 1; level=0 XX Names: PgsA XX ID PGSA DE RecName: Full=CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; DE EC=2.7.8.5; DE AltName: Full=Phosphatidylglycerophosphate synthase; DE Short=PGP synthase; GN Name=pgsA; XX CC -!- FUNCTION: This protein catalyzes the committed step to the synthesis of CC the acidic phospholipids. CC -!- CATALYTIC ACTIVITY: CC Reaction=a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = 1,2- CC diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + CC H(+); Xref=Rhea:RHEA:12593, ChEBI:CHEBI:15378, ChEBI:CHEBI:57597, CC ChEBI:CHEBI:58332, ChEBI:CHEBI:60110, ChEBI:CHEBI:60377; EC=2.7.8.5; CC -!- PATHWAY: Phospholipid metabolism; phosphatidylglycerol biosynthesis; CC phosphatidylglycerol from CDP-diacylglycerol: step 1/2. CC -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the CDP-alcohol phosphatidyltransferase class-I CC family. XX DR PROSITE; PS00379; CDP_ALCOHOL_P_TRANSF; 1; trigger=no DR Pfam; PF01066; CDP-OH_P_transf; 1; trigger=no DR NCBIfam; TIGR00560; PgsA; 1; trigger=no XX KW Cell membrane KW Cell inner membrane KW Lipid biosynthesis KW Lipid metabolism KW Membrane KW Phospholipid biosynthesis KW Phospholipid metabolism KW Transferase KW Transmembrane KW Transmembrane helix XX GO GO:0008444; F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity GO GO:0008654; P:phospholipid biosynthetic process GO GO:0005886; C:plasma membrane XX FT From: PGSA_ECOLI (P0ABF8) FT TOPO_DOM 1..12 FT /note="Cytoplasmic" FT TRANSMEM 13..37 FT /note="Helical" FT TOPO_DOM 38..60 FT /note="Periplasmic" FT TRANSMEM 61..81 FT /note="Helical" FT TOPO_DOM 82..86 FT /note="Cytoplasmic" FT TRANSMEM 87..107 FT /note="Helical" FT TOPO_DOM 108..145 FT /note="Periplasmic" FT TRANSMEM 146..168 FT /note="Helical" FT TOPO_DOM 169..181 FT /note="Cytoplasmic" XX Size: 181-190; Related: None; Template: P0ABF8; Scope: Bacteria; Enterobacterales Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.21 2023/06/01 //