AC   MF_01441;
DC   Protein; auto
TR   HAMAP; MF_01441; -; 1; level=0
XX
Names: Dps
XX
ID   DPS
DE   RecName: Full=DNA protection during starvation protein;
DE            EC=1.16.-.-;
GN   Name=dps;
XX
case <OC:Escherichia> or <OC:Shigella>
CC   -!- FUNCTION: During stationary phase, binds the chromosome non-
CC       specifically, forming a highly ordered and stable dps-DNA co-crystal
CC       within which chromosomal DNA is condensed and protected from diverse
CC       damages. It protects DNA from oxidative damage by sequestering
CC       intracellular Fe(2+) ion and storing it in the form of Fe(3+)
CC       oxyhydroxide mineral, which can be released after reduction. One
CC       hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl
CC       radical production by the Fenton reaction. Dps also protects the cell
CC       from UV and gamma irradiation, iron and copper toxicity, thermal stress
CC       and acid and base shocks. Also shows a weak catalase activity.
end case
case not <OC:Escherichia> and not <OC:Shigella>
CC   -!- FUNCTION: During stationary phase, binds the chromosome non-
CC       specifically, forming a highly ordered and stable dps-DNA co-crystal
CC       within which chromosomal DNA is condensed and protected from diverse
CC       damages. It protects DNA from oxidative damage by sequestering
CC       intracellular Fe(2+) ion and storing it in the form of Fe(3+)
CC       oxyhydroxide mineral, which can be released after reduction. One
CC       hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl
CC       radical production by the Fenton reaction.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 Fe(2+) + 2 H(+) + H2O2 = 2 Fe(3+) + 2 H2O;
CC         Xref=Rhea:RHEA:48712, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:29033, ChEBI:CHEBI:29034;
CC   -!- SUBUNIT: Homododecamer. The 12 subunits form a hollow sphere into which
CC       the mineral iron core of up to 500 Fe(3+) can be deposited.
case <OC:Escherichia> or <OC:Shigella>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid.
end case
case not <OC:Escherichia> and not <OC:Shigella>
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
end case
CC   -!- SIMILARITY: Belongs to the Dps family.
XX
DR   PROSITE; PS00818; DPS_1; 1; trigger=no
DR   PROSITE; PS00819; DPS_2; 1; trigger=no
DR   Pfam; PF00210; Ferritin; 1; trigger=no
DR   PRINTS; PR01346; HELNAPAPROT; 1; trigger=no
XX
KW   Cytoplasm
KW   DNA condensation
KW   DNA-binding
KW   Iron
KW   Iron storage
KW   Metal-binding
KW   Oxidoreductase
XX
GO   GO:0008199; F:ferric iron binding
GO   GO:0003677; F:DNA binding
GO   GO:0016491; F:oxidoreductase activity
GO   GO:0005737; C:cytoplasm
XX
FT   From: DPS_ECOLI (P0ABT2)
case <OC:Escherichia> or <OC:Shigella>
FT   BINDING         51
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between two dodecameric
FT                   partners"
FT   Condition: H
FT   BINDING         78
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between two dodecameric
FT                   partners"
FT                   /note="in other chain"
FT   Condition: D
FT   BINDING         82
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="1"
FT                   /ligand_note="ligand shared between two dodecameric
FT                   partners"
FT                   /note="in other chain"
FT   Condition: E
FT   BINDING         82
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_label="2"
FT   Condition: E
end case
case not <OC:Escherichia> and not <OC:Shigella>
FT   BINDING         51
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Condition: H
FT   BINDING         78
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Condition: D
FT   BINDING         82
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Condition: E
end case
XX
Size: 166-169;
Related: None;
Template: P0ABT2;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.20 2022/11/19
//