AC   MF_01451;
DC   Protein; auto
TR   HAMAP; MF_01451; -; 1; level=0
XX
Names: AddA
XX
ID   ADDA
DE   RecName: Full=ATP-dependent helicase/nuclease subunit A;
DE            EC=3.1.-.-;
DE            EC=5.6.2.4;
DE   AltName: Full=ATP-dependent helicase/nuclease AddA;
DE   AltName: Full=DNA 3'-5' helicase AddA;
GN   Name=addA;
XX
CC   -!- FUNCTION: The heterodimer acts as both an ATP-dependent DNA helicase
CC       and an ATP-dependent, dual-direction single-stranded exonuclease.
CC       Recognizes the chi site generating a DNA molecule suitable for the
CC       initiation of homologous recombination. The AddA nuclease domain is
CC       required for chi fragment generation; this subunit has the helicase and
CC       3' -> 5' nuclease activities.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC         translocating in the 3'-5' direction.; EC=5.6.2.4;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- SUBUNIT: Heterodimer of AddA and AddB/RexB.
CC   -!- SIMILARITY: Belongs to the helicase family. AddA subfamily.
XX
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1; trigger=yes
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 1; trigger=yes
DR   Pfam; PF00580; UvrD-helicase; 1; trigger=no
DR   NCBIfam; TIGR02785; AddA_Gpos; 1; trigger=no
XX
KW   ATP-binding
KW   DNA damage
KW   DNA repair
KW   DNA-binding
KW   Exonuclease
KW   Helicase
KW   Hydrolase
KW   Isomerase
KW   Nuclease
KW   Nucleotide-binding
XX
GO   GO:0003678; F:DNA helicase activity
GO   GO:0005524; F:ATP binding
GO   GO:0043138; F:3'-5' DNA helicase activity
GO   GO:0008408; F:3'-5' exonuclease activity
GO   GO:0003690; F:double-stranded DNA binding
GO   GO:0000724; P:double-strand break repair via homologous recombination
XX
FT   None
XX
Size: 1167-1405;
Related: None;
Template: P23478; A2RH77; Q97QP9;
Scope:
 Bacteria; Bacillota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Originally called rexA in Lactobacillus and Streptococcus. Forms
 a heterodimer with 1 of 2 related proteins; in Bacillus and Staphylococcus
 the partner is addB, in Lactobacillus and Streptococcus the partner is
 rexB.
XX
# Revision 1.17 2023/11/13
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