AC   MF_01452;
DC   Protein; auto
TR   HAMAP; MF_01452; -; 1; level=0
XX
Names: AddB_type1
XX
ID   ADDB
DE   RecName: Full=ATP-dependent helicase/deoxyribonuclease subunit B;
DE            EC=3.1.-.-;
DE   AltName: Full=ATP-dependent helicase/nuclease subunit AddB;
GN   Name=addB;
XX
CC   -!- FUNCTION: The heterodimer acts as both an ATP-dependent DNA helicase
CC       and an ATP-dependent, dual-direction single-stranded exonuclease.
CC       Recognizes the chi site generating a DNA molecule suitable for the
CC       initiation of homologous recombination. The AddB subunit has 5' -> 3'
CC       nuclease activity but not helicase activity.
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster.;
end case
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- SUBUNIT: Heterodimer of AddA and AddB.
CC   -!- MISCELLANEOUS: Despite having conserved helicase domains, this subunit
CC       does not have helicase activity.
CC   -!- SIMILARITY: Belongs to the helicase family. AddB/RexB type 1 subfamily.
XX
DR   Pfam; PF21445; ADDB_N; 1; trigger=no
DR   Pfam; PF12705; PDDEXK_1; 1; trigger=no
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 0-1; trigger=yes
DR   PROSITE; PS51217; UVRD_HELICASE_CTER; 0-1; trigger=yes
DR   NCBIfam; TIGR02773; AddB_Gpos; 1; trigger=no
XX
KW   ATP-binding
KW   DNA damage
KW   DNA repair
KW   DNA-binding
KW   Exonuclease
KW   Helicase
KW   Hydrolase
KW   Nuclease
KW   Nucleotide-binding
case <FTGroup:1>
KW   4Fe-4S
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
end case
XX
GO   GO:0005524; F:ATP binding
GO   GO:0008409; F:5'-3' exonuclease activity
GO   GO:0003690; F:double-stranded DNA binding
case <FTGroup:1>
GO   GO:0051536; F:iron-sulfur cluster binding
end case
GO   GO:0000724; P:double-strand break repair via homologous recombination
XX
FT   From: ADDB_BACSU (P23477)
FT   BINDING         801
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Optional; Group: 1; Condition: C
FT   BINDING         1121
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Optional; Group: 1; Condition: C
FT   BINDING         1124
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Optional; Group: 1; Condition: C
FT   BINDING         1130
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Optional; Group: 1; Condition: C
XX
Size: 1134-1224;
Related: MF_01453;
Template: P23477;
Scope:
 Bacteria; Bacillota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Two related subfamiles of this protein exist; addB in Bacillus
 and Staphylococcus (this family), and rexB in Lactobacillus and
 Streptococcus (MF_01453). In most Lactobacillales there is no 4Fe-4S
 center; this has been suggested (PubMed:19129187) to occur in organisms
 which inhabit a low-iron environment.
 Not all members match the uvrD_helicase profiles (PS51198 and PS51217).
XX
# Revision 1.20 2023/11/10
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