AC   MF_01465;
DC   Protein; auto
c?   <OC:Bacteria> or <OC:Archaea> or <OG:Chloroplast>
TR   HAMAP; MF_01465; -; 1; level=0
XX
Names: SecY
XX
ID   SECY
case <OC:Bacteria> or <OG:Chloroplast>
DE   RecName: Full=Protein translocase subunit SecY;
else case <OC:Archaea>
DE   RecName: Full=Protein translocase subunit SecY;
DE   AltName: Full=Protein transport protein SEC61 subunit alpha homolog;
end case
GN   Name=secY;
XX
case <OC:Bacteria> or <OC:Archaea>
CC   -!- FUNCTION: The central subunit of the protein translocation channel
CC       SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two
CC       domains form a lateral gate at the front which open onto the bilayer
CC       between TMs 2 and 7, and are clamped together by SecE at the back. The
CC       channel is closed by both a pore ring composed of hydrophobic SecY
CC       resides and a short helix (helix 2A) on the extracellular side of the
CC       membrane which forms a plug. The plug probably moves laterally to allow
CC       the channel to open. The ring and the pore may move independently.
else case <OG:Chloroplast>
CC   -!- FUNCTION: The central subunit of the protein translocation channel
CC       SecYE. Consists of two halves formed by TMs 1-5 and 6-10. These two
CC       domains form a lateral gate at the front which open onto the bilayer
CC       between TMs 2 and 7, and are clamped together by SecE at the back. The
CC       channel is closed by both a pore ring composed of hydrophobic SecY
CC       resides and a short helix (helix 2A) on the extracellular side of the
CC       membrane which forms a plug.
end case
case <OC:Bacteria>
CC   -!- SUBUNIT: Component of the Sec protein translocase complex. Heterotrimer
CC       consisting of SecY, SecE and SecG subunits. The heterotrimers can form
CC       oligomers, although 1 heterotrimer is thought to be able to translocate
CC       proteins. Interacts with the ribosome. Interacts with SecDF, and other
CC       proteins may be involved. Interacts with SecA.
else case <OC:Archaea>
CC   -!- SUBUNIT: Component of the Sec protein translocase complex. Heterotrimer
CC       consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The
CC       heterotrimers can form oligomers, although 1 heterotrimer is thought to
CC       be able to translocate proteins. Interacts with the ribosome. May
CC       interact with SecDF, and other proteins may be involved.
else case <OG:Chloroplast>
CC   -!- SUBUNIT: Component of the plastid Sec protein translocase complex,
CC       which is composed of at least SecY and SecE.
end case
case <OG:Chloroplast>
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast thylakoid membrane; Multi-
CC       pass membrane protein.
else case <OC:Cyanobacteriota> and not <OC:Gloeobacter>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC       Cellular thylakoid membrane; Multi-pass membrane protein.
else case <OC:Gloeobacter>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
else case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the SecY/SEC61-alpha family.
XX
DR   PROSITE; PS00755; SECY_1; 1; trigger=no
DR   PROSITE; PS00756; SECY_2; 1; trigger=no
DR   Pfam; PF10559; Plug_translocon; 1; trigger=no
DR   Pfam; PF00344; SecY; 1; trigger=no
DR   PRINTS; PR00303; SECYTRNLCASE; 1; trigger=no
DR   NCBIfam; TIGR00967; 3a0501s007; 1; trigger=no
DR   PIRSF; PIRSF004557; SecY; 1; trigger=no
DR   General; Transmembrane; -; 10; trigger=yes
XX
case <OG:Chloroplast>
KW   Thylakoid
else case <OC:Cyanobacteriota> and not <OC:Gloeobacter>
KW   Cell membrane
KW   Cell inner membrane
KW   Thylakoid
else case <OC:Gloeobacter>
KW   Cell membrane
KW   Cell inner membrane
else case not defined <Property:Membrane> or <Property:Membrane=1>
KW   Cell membrane
else case <Property:Membrane=2>
KW   Cell membrane
KW   Cell inner membrane
end case
KW   Membrane
KW   Protein transport
KW   Translocation
KW   Transmembrane
KW   Transmembrane helix
KW   Transport
XX
GO   GO:0065002; P:intracellular protein transmembrane transport
GO   GO:0006605; P:protein targeting
case <OC:Bacteria>
GO   GO:0043952; P:protein transport by the Sec complex
end case
case <OC:Cyanobacteriota> and not <OC:Gloeobacter>
GO   GO:0042651; C:thylakoid membrane
else case <OG:Chloroplast>
GO   GO:0009535; C:chloroplast thylakoid membrane
else
GO   GO:0005886; C:plasma membrane
end case
XX
FT   None
XX
Size: 340-661;
Related: MF_01466;
Template: Q60175; O66491; P0AGA2; Q5SHQ8; Q8U019; Q9X1I9;
Scope:
 Bacteria
 Archaea
 Plastid
Fusion:
 Nter: None
 Cter: None
Duplicate: in LACKZ
Plasmid: in LACKZ
Comments: Unless there is a crystal structure we do not usually try to
 annotate the discontinuous transmembrane helix 2. A second, related SecY2
 is encoded in some Staphylococcus and Streptococcus genomes (MF_01466); it
 is required for export of a large cell wall protein in the few organisms
 where it has been characterized. The 2 familes, while related, do not
 overlap.
XX
# Revision 1.9 2023/06/01
//