AC MF_01471; DC Protein; auto TR HAMAP; MF_01471; -; 1; level=0 XX Names: Cas2 XX ID CAS2 DE RecName: Full=CRISPR-associated endoribonuclease Cas2; DE EC=3.1.-.-; GN Name=cas2; XX CC -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic CC repeat), is an adaptive immune system that provides protection against CC mobile genetic elements (viruses, transposable elements and conjugative CC plasmids). CRISPR clusters contain sequences complementary to CC antecedent mobile elements and target invading nucleic acids. CRISPR CC clusters are transcribed and processed into CRISPR RNA (crRNA). CC Functions as a ssRNA-specific endoribonuclease. Involved in the CC integration of spacer DNA into the CRISPR cassette. case CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; end case CC -!- SUBUNIT: Homodimer, forms a heterotetramer with a Cas1 homodimer. CC -!- SIMILARITY: Belongs to the CRISPR-associated endoribonuclease Cas2 CC protein family. XX DR Pfam; PF09827; CRISPR_Cas2; 1; trigger=no DR NCBIfam; TIGR01573; Cas2; 1; trigger=no XX KW Antiviral defense KW Endonuclease KW Hydrolase case KW Magnesium KW Metal-binding end case KW Nuclease XX GO GO:0004519; F:endonuclease activity case GO GO:0046872; F:metal ion binding end case GO GO:0051607; P:defense response to virus GO GO:0043571; P:maintenance of CRISPR repeat elements XX FT From: CAS2A_SACS2 (Q97YC2) FT BINDING 10 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /ligand_note="catalytic" FT Condition: [DE] XX Size: 85-143; Related: None; Template: Q97YC2; Q82W51; Q9X2B6; O28403; O27155; Q97Y85; Scope: Bacteria Archaea Fusion: Nter: None Cter: None Duplicate: in ARCFU, CHLAA, LACRG, METHJ, MOOTA, NITEU, PYRAE, RHORT, SACS2, SYNY3, THEYD Plasmid: in ALLVD, DESVH, SYNY3, THET8 Comments: Found in almost all CRISPR systems. In Bacillus halodurans and Thermus thermophilus is a dsDNase. XX # Revision 1.12 2023/06/01 //