AC   MF_01479;
DC   Protein; auto
TR   HAMAP; MF_01479; -; 1; level=0
XX
Names: WhiB
XX
ID   WHIB
DE   RecName: Full=Transcriptional regulator WhiB;
GN   Name=whiB;
XX
CC   -!- FUNCTION: Acts as a transcriptional regulator. Probably redox-
CC       responsive. The apo- but not holo-form probably binds DNA.
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of
CC       the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- PTM: The Fe-S cluster can be nitrosylated by nitric oxide (NO).
CC   -!- PTM: Upon Fe-S cluster removal intramolecular disulfide bonds are
CC       formed.
CC   -!- SIMILARITY: Belongs to the WhiB family.
XX
DR   Pfam; PF02467; Whib; 1; trigger=no
XX
case <FTGroup:1>
KW   4Fe-4S
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
end case
KW   Cytoplasm
KW   Disulfide bond
KW   DNA-binding
KW   Transcription
KW   Transcription regulation
XX
GO   GO:0051539; F:4 iron, 4 sulfur cluster binding
GO   GO:0005737; C:cytoplasm
GO   GO:0006355; P:regulation of DNA-templated transcription
GO   GO:0003677; F:DNA binding
GO   GO:0035731; F:dinitrosyl-iron complex binding
XX
FT   From: WHIB1_MYCTU (P9WF43)
FT   BINDING         9
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         37
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         40
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         46
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
XX
Size: 76-306;
Related: None;
Template: P9WF43; P9WF41; P9WF39; Q7AKI9;
Scope:
 Bacteria; Actinomycetota
Fusion:
 Nter: None
 Cter: None
Duplicate: in BIFLO, MYCBO, MYCS2, MYCTU, STRCO
Plasmid: None
Comments: None
XX
# Revision 1.16 2023/01/13
//