AC MF_01482; DC Protein; auto TR HAMAP; MF_01482; -; 1; level=0 XX Names: Mca XX ID MCA DE RecName: Full=Mycothiol S-conjugate amidase; DE EC=3.5.1.115; GN Name=mca; XX CC -!- FUNCTION: A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- CC conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine CC conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH CC precursor. Involved in MSH-dependent detoxification of a number of CC alkylating agents and antibiotics. CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy- CC alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate; CC Xref=Rhea:RHEA:36543, ChEBI:CHEBI:15377, ChEBI:CHEBI:58718, CC ChEBI:CHEBI:58886, ChEBI:CHEBI:59633; EC=3.5.1.115; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Note=Binds 1 zinc ion per subunit.; CC -!- SUBUNIT: Monomer. CC -!- SIMILARITY: Belongs to the MshB deacetylase family. Mca subfamily. XX DR Pfam; PF02585; PIG-L; 1; trigger=no DR NCBIfam; TIGR03446; mycothiol_Mca; 1; trigger=no XX GO GO:0008270; F:zinc ion binding GO GO:0010126; P:mycothiol metabolic process GO GO:0010127; P:mycothiol-dependent detoxification XX KW Hydrolase KW Metal-binding KW Zinc XX FT From: MCA_MYCTU (P9WJN1) FT BINDING 12 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT Condition: H FT BINDING 15 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT Condition: D FT BINDING 142 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT Condition: H XX Size: 255-420; Related: None; Template: A0R2W9; P9WJN1; Q9ADK0; Scope: Bacteria; Actinomycetota Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.12 2023/06/01 //