AC   MF_01486;
DC   Protein; auto
TR   HAMAP; MF_01486; -; 1; level=0
XX
Names: RecC
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ID   RECC
DE   RecName: Full=RecBCD enzyme subunit RecC;
DE   AltName: Full=Exonuclease V subunit RecC;
DE            Short=ExoV subunit RecC;
DE   AltName: Full=Helicase/nuclease RecBCD subunit RecC;
GN   Name=recC;
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CC   -!- FUNCTION: A helicase/nuclease that prepares dsDNA breaks (DSB) for
CC       recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly
CC       rapid and processive ATP-dependent bidirectional helicase activity.
CC       Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator)
CC       sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the
CC       Chi site. The properties and activities of the enzyme are changed at
CC       Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and
CC       facilitates RecA-binding to the ssDNA for homologous DNA recombination
CC       and repair. Holoenzyme degrades any linearized DNA that is unable to
CC       undergo homologous recombination. In the holoenzyme this subunit
CC       recognizes the wild-type Chi sequence, and when added to isolated RecB
CC       increases its ATP-dependent helicase processivity.
CC   -!- SUBUNIT: Heterotrimer of RecB, RecC and RecD. All subunits contribute
CC       to DNA-binding.
CC   -!- MISCELLANEOUS: In the RecBCD complex, RecB has a slow 3'-5' helicase,
CC       an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'-
CC       3' helicase activity, while RecC stimulates the ATPase and processivity
CC       of the RecB helicase and contributes to recognition of the Chi site.
CC   -!- SIMILARITY: Belongs to the RecC family.
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DR   Pfam; PF04257; Exonuc_V_gamma; 1; trigger=no
DR   Pfam; PF17946; RecC_C; 1; trigger=no
DR   NCBIfam; TIGR01450; recC; 1; trigger=no
DR   PIRSF; PIRSF000980; RecC; 1; trigger=no
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KW   ATP-binding
KW   DNA damage
KW   DNA repair
KW   DNA-binding
KW   Exonuclease
KW   Helicase
KW   Hydrolase
KW   Nuclease
KW   Nucleotide-binding
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GO   GO:0003678; F:DNA helicase activity
GO   GO:0005524; F:ATP binding
GO   GO:0003677; F:DNA binding
GO   GO:0000724; P:double-strand break repair via homologous recombination
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FT   None
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Size: 1028-1375;
Related: None;
Template: P07648;
Scope:
 Bacteria; Actinomycetota
 Bacteria; Bacteroidota
 Bacteria; Chlamydiota
 Bacteria; Chlorobiota
 Bacteria; Deferribacteres
 Bacteria; Pseudomonadota
 Bacteria; Spirochaetota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in PARRH, GORPV, SHEB5
Comments: None
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# Revision 1.16 2023/11/10
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