AC   MF_01488;
DC   Protein; auto
TR   HAMAP; MF_01488; -; 1; level=0
XX
Names: RecD2
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ID   RECD2
DE   RecName: Full=ATP-dependent RecD2 DNA helicase;
DE            EC=5.6.2.3;
DE   AltName: Full=DNA 5'-3' helicase subunit RecD2;
GN   Name=recD2;
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CC   -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC       Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC       least 10 bases of 5'-ssDNA for helicase activity.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA at the
CC         replication fork by translocating in the 5'-3' direction. This
CC         creates two antiparallel DNA single strands (ssDNA). The leading
CC         ssDNA polymer is the template for DNA polymerase III holoenzyme which
CC         synthesizes a continuous strand.; EC=5.6.2.3;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.3;
CC   -!- SIMILARITY: Belongs to the RecD family. RecD2 subfamily.
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DR   Pfam; PF13538; UvrD_C_2; 1; trigger=no
DR   NCBIfam; TIGR01448; recD_rel; 1; trigger=no
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case <FT:1>
KW   ATP-binding
KW   Nucleotide-binding
end case
KW   DNA-binding
KW   Helicase
KW   Hydrolase
KW   Isomerase
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GO   GO:0043139; F:5'-3' DNA helicase activity
case <FT:1>
GO   GO:0005524; F:ATP binding
end case
GO   GO:0003677; F:DNA binding
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FT   From: RECD2_DEIRA (Q9RT63)
FT   BINDING         363..367
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-[TMVKC]-G-K-[ST]
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Size: 688-865;
Related: MF_01487;
Template: Q9RT63; O34481;
Scope:
 Bacteria; Actinomycetota
 Bacteria; Chlamydiota
 Bacteria; Chlorobiota
 Bacteria; Chloroflexota
 Bacteria; Cyanobacteriota
 Bacteria; Deinococcota
 Bacteria; Bacillota
 Bacteria; Pseudomonadota
 Bacteria; Synergistota
 Bacteria; Mycoplasmatota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in DEIPM, PAEPS
Comments: The RecD2 helicase is not associated with RecB and RecC, although a
 few organisms have both genes. Its physiological role varies in the few
 bacteria where it has been characterized.
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# Revision 1.13 2023/12/14
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