AC MF_01497; DC Protein; auto TR HAMAP; MF_01497; -; 1; level=0 XX Names: SrkA_kinase XX ID SRKA DE RecName: Full=Stress response kinase A; DE EC=2.7.11.1; DE AltName: Full=Serine/threonine-protein kinase SrkA; GN Name=srkA; XX CC -!- FUNCTION: A protein kinase that phosphorylates Ser and Thr residues. CC Probably acts to suppress the effects of stress linked to accumulation CC of reactive oxygen species. Probably involved in the extracytoplasmic CC stress response. CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; CC EC=2.7.11.1; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC -!- SUBUNIT: Monomer. CC -!- SUBCELLULAR LOCATION: Cytoplasm. CC -!- SIMILARITY: Belongs to the SrkA/RdoA protein kinase family. XX DR Pfam; PF01636; APH; 1; trigger=no XX KW ATP-binding KW Cytoplasm KW Kinase KW Magnesium KW Metal-binding KW Nucleotide-binding KW Phosphoprotein KW Serine/threonine-protein kinase KW Stress response KW Transferase XX GO GO:0004674; F:protein serine/threonine kinase activity GO GO:0005524; F:ATP binding GO GO:0000287; F:magnesium ion binding GO GO:0005737; C:cytoplasm XX FT From: SRKA_ECOLI (P0C0K3) FT ACT_SITE 201 FT /note="Proton acceptor" FT Condition: D FT ACT_SITE 217 FT Condition: D FT BINDING 206 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Condition: N FT BINDING 217 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT Condition: D FT SITE 36 FT /note="ATP" FT Condition: S XX Size: 280-416; Related: None; Template: P0C0K3; Q8ZKU8; Q83IV7; Scope: Bacteria Fusion: Nter: None Cter: None Duplicate: None Plasmid: in LEPBP Comments: None XX # Revision 1.7 2022/11/19 //