AC   MF_01499;
DC   Protein; auto
TR   HAMAP; MF_01499; -; 1; level=0
XX
Names: DacA
XX
ID   DACA
DE   RecName: Full=Diadenylate cyclase;
DE            Short=DAC;
DE            EC=2.7.7.85;
DE   AltName: Full=Cyclic-di-AMP synthase;
DE            Short=c-di-AMP synthase;
GN   Name=dacA;
XX
CC   -!- FUNCTION: Catalyzes the condensation of 2 ATP molecules into cyclic di-
CC       AMP (c-di-AMP), a second messenger used to regulate differing processes
CC       in different bacteria.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2 ATP = 3',3'-c-di-AMP + 2 diphosphate; Xref=Rhea:RHEA:35655,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:71500; EC=2.7.7.85;
CC   -!- SUBUNIT: Probably a homodimer.
case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane==1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Single-pass membrane protein.
else case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane>1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2> and <Feature:Transmembrane==1>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane
CC       protein.
else case <Property:Membrane=2> and <Feature:Transmembrane>1>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the adenylate cyclase family. DacA/CdaA
CC       subfamily.
XX
DR   PROSITE; PS51794; DAC; 1; trigger=yes
DR   Pfam; PF02457; DisA_N; 1; trigger=no
DR   NCBIfam; TIGR00159; TIGR00159; 1; trigger=no
DR   PIRSF; PIRSF004793; UCP004793; 1; trigger=no
DR   General; Transmembrane; -; 1-3; trigger=yes
XX
KW   ATP-binding
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Cell membrane
KW   Membrane
KW   Nucleotide-binding
KW   Nucleotidyltransferase
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
XX
GO   GO:0004016; F:adenylate cyclase activity
GO   GO:0005524; F:ATP binding
GO   GO:0016779; F:nucleotidyltransferase activity
GO   GO:0019932; P:second-messenger-mediated signaling
XX
FT   None
XX
Size: 200-386;
Related: MF_00838; MF_00840; MF_01438;
Template: Q8Y5E4; Q45589;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Not found in all bacterial lineages. A few proteins also have
 the YbbR domain that may be associated with a DAC stimulatory activity.
XX
# Revision 1.8 2023/06/01
//